Nephrotic Syndrome Due to Primary Systemic AL Amyloidosis, Successfully Treated with VAD (Vincristine, Doxorubicin and Dexamethasone) Alone
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概要
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We report 3 patients with nephrotic syndrome ascribed to primary systemic AL amyloidosis that were successfully treated with VAD (vincristine, doxorubicin and dexamethasone) alone. M-protein in serum disappeared soon after VAD, and nephrotic syndrome gradually improved in parallel with a decrease in daily protein excretion in urine. Long-term follow-up of these patients showed neither relapse of nephrotic syndrome nor reappearance of M-protein. High-dose melphalan followed by autologous stem cell support is a standard therapy for primary systemic AL amyloidosis, but in high-risk cases for this treatment, such as elderly patients and those with multiple organ involvement, VAD might be a therapeutic option.
- 社団法人 日本内科学会の論文
著者
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Yoshida Takuhiro
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Matsuda Masayuki
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Katoh Nagaaki
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Tazawa Ko-ichi
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Shimojima Yasuhiro
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Gono Takahisa
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Ishii Wataru
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Fushimi Tomohisa
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Fushimi Tomohisa
Department Of Internal Medicine Fujimi-kogen Hospital
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Ikeda Shu-ichi
Department Of Internal Medicine (neurology And Rheumatology) Shinshu University School Of Medicine
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Fushimi Tomohisa
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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