Preparation of N-Monoalkyl and O-Acyl Derivatives of Allosamidin, and Their Chitinase Inhibitory Activities

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概要

• 論文の詳細を見る

• Allosamidin (1) was converted to demethylallosamidin (2) and didemethylallosamidin (3) by a reaction with methylamine and ammonia, respectively. In the same way, a series of N-monoalkyl derivatives was prepared from 1 and 2. A variety of 6- and 6"-O-acyl derivatives of 1 was also prepared by chemically selective acylation. The inhibitory activity of each of these derivatives on chitinases originating from insects and fungi showed that a monomethylaminooxazoline or dimethylaminooxazoline structure was important for strong activity, and that the 6"-O-acyl derivatives of 1 each retained relatively high activity.

• 社団法人日本農芸化学会の論文
• 1993-10-23

著者

• Yamada Yasuhiro

  Department Of Biotechnology Osaka University

• Yamada Y

  Osaka Univ. Osaka Jpn

• SAKUDA Shohei

  Department of Applied Biological Chemistry, University of Tokyo

• Sakuda Shohei

  Department Of Biotechnology Faculty Of Engineering Osaka University

• Sakuda Shohei

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Kinoshita Masayoshi

  Department Of Bioapplied Chemistry Faculty Of Engineering Osaka City University

• Kinoshita M

  Obihiro Univ. Agriculture And Veterinary Medicine Obihiro Jpn

• Yamada Yasuhiro

  Department Of Agricultural Chemistry Faculty Of Agriculture University Of Tokyo

• SAKUDA Shohei

  Department of Agricultural Chemistry, The University of Tokyo

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