Methylation of pyrimidine 2'-deoxynucleosides with trimethyl phosphate.
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概要
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The reactions of thymidine, deoxyuridine, and deoxycytidine with trimethyl phosphate (TMP) were studied in a homogeneous water solution at 37–60 °C and pH 7–10. Three pyrimidine deoxynucleosides were methylated mainly at the N-3 position to afford their 3-methyl derivatives. The methylation rate at the N-3 position was found to be dependent on the pH of reaction medium. At pH 10, thymidine and deoxyuridine were methylated much faster than deoxycytidine, the tendency being reversed at pH 7.
- 公益社団法人 日本化学会の論文
著者
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Kinoshita Masayoshi
Department Of Bioapplied Chemistry Faculty Of Engineering Osaka City University
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Yamauchi Kiyoshi
Department Of Bioapplied Chemistry Faculty Of Engineering Osaka City University
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Tanabe Toshizumi
Department of Applied Chemistry & Bioengineering, Graduate School of Engineering, Osaka City University
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