1,1'-(1,32-Dotriacontanediyl)bis(2-acetyl-sn-glycero(3)phosphocholine): A long persisting agonist as a potential antihypertension agent.
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概要
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A dimer of platelet activating factor (PAF), 1,1′-(1,32-dotriacontanediyl)bis[2-acetyl-<I>sn</I>-glycero(3)phosphocholine] (<B>7</B>), was synthesized and examined for platelet aggregation and antihypertension activities. The compound <B>7</B> showed both activities with the maximum levels of 1/50–1/100-fold of those of PAF, but the antihypertension effect of <B>7</B> persisted much longer and appeared with time lag of 1–3 min. The unique expression of the activities was discussed in conjunction with the molecular structure.
- 公益社団法人 日本化学会の論文
著者
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Kinoshita Masayoshi
Department Of Bioapplied Chemistry Faculty Of Engineering Osaka City University
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KONDO Takao
Research Division, The Green Cross Corporation
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Yamauchi Kiyoshi
Department Of Bioapplied Chemistry Faculty Of Engineering Osaka City University
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Watanabe Masahiro
Research Center For Quantum Effect Electronics Tokyo Institute Of Technology
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WATANABE Masahiro
Research Division, The Green Cross Corporation
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Hihara Mitsuyoshi
Department of Applied Chemistry, Osaka City University
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Kuwahara Shigeki
Research Division, the Green Cross Corporation
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Kinoshita Masayoshi
Department of Applied Chemistry, Faculty of Engineering, Osaka City University
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