Serum Hepatocyte Growth Factor Predicts Ventricular Remodeling Following Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
Hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) stimulate endothelial cell proliferation and induce angiogenesis, but the timing and significance of their release in patients with acute myocardial infarction (AMI) are unknown in relation to future left ventricular remodeling. Venous blood samples were obtained at admission and up to 3 weeks later in 40 patients with AMI and in 40 age- and sex-matched control subjects. Blood samples were also taken from the coronary sinus (CS) in 20 patients on day 7 following AMI. Left ventricular end-diastolic volume in the subacute (1 week) and chronic (3 months) phases was assessed by left ventriculography to identify the remodeling group (n=15), which was defined as an increase in left ventricular end-diastolic volume index ≥5 ml/m^2 relative to the baseline value. Serum HGF and VEGF concentrations were higher in newly admitted patients with AMI than in the controls (HGF, 0.33★0.09 vs 0.24★0.08 ng/ml, p<0.01; VEGF 92.2+43.1 vs 67.2★29.8 pg/ml, p<0.01), peaking on day 7 (HGF, 0.41★0.12; VEGF, 161.7★76.9), and gradually decreasing between days 14 and 21. The HGF concentration in the CS did not differ from the concentration in the periphery, but the VEGF concentration was significantly more abundant in the CS than in the peripheral sample on day 7 (p<0.05). The serum HGF concentration on day 7 was higher in the remodeling group than in the nonremodeling group (0.47★0.13 vs 0.36★0.09 ng/ml, p<0.01), but there was no difference between the groups on admission, day 14 and day 21. The serum VEGF concentration did not differ between the remodeling and nonremodeling groups at any time. Thus, the serum HGF concentration on day 7 after AMI is mostly from noncardiac sources and predicts left ventricular remodeling.
- 社団法人日本循環器学会の論文
- 2002-10-20
著者
-
FUKUDA Nobuo
Department of Cardiology and Clinical Research, National Hospital Organization Zentsuji Hospital
-
SAKABE Koichi
Department of Cardiology and Clinical Research, National Hospital Organization Zentsuji Hospital
-
SHINOHARA Hisanori
Department of Cardiology and Clinical Research, National Hospital Organization Zentsuji Hospital
-
TAMURA Yoshiyuki
Department of Cardiology and Clinical Research, National Hospital Organization Zentsuji Hospital
-
Fnkuda Nobuo
Department Of Cardiology And Clinical Research National Hospital Organization Zentsuji Hospital
-
Fukuda N
National Institute Of Radiological Sciences
-
Fukuda Nobuo
Tsukuba Research Laboratory Nof Coproration
-
Sakabe Koichi
Department Of Cardiology And Clinical Reseach National Hospital Organazation Zentsuji Hospital
-
Soeki Takeshi
Department of Biochemistry, National Cardiovascular Center Research Institute
-
Onose Yukiko
Department Of Cardiology And Clinical Research National Zentsuji Hospital
-
Sakabe Koichi
The Second Department Of Internal Medicine School Of Medicine The University Of Tokushirna
-
Takiuchi Shin
Division Of Hypertension And Nephrology National Cardiovascular Center
-
Sugihara Takashi
Division Of Cardiovascular Medicine Tokushima University Hospital
-
Tamura Yoshiyuki
Department Of Cardiology And Clinical Research National Hospital Organization Zentsuji Hospital
-
Shinohara Hisanori
Department Of Cardiology And Clinical Research National Hospital Organization Zentsuji Hospital
-
Shinohara Hisanori
Department Of Internal Medicine And Clinical Research National Zentsuji Hospital
-
Sakabe Kouichi
The Second Department Of Internal Medicine School Of Medicine The Univercity Of Tokushima
-
Shinohara Hisanori
Department Of Cardiology And Clinical Research
関連論文
- Diastolic flow velocity pattern of the left anterior descending coronary artery in hypertrophied heart, with special reference to the difference between hypertrophic cardiomyopathy and hypertensive left ventricular hypertrophy
- High Resolution CNT-FED and Improvement in Field-Emission Characteristics
- Field Ion-Scanning Tunneling Microscopy Study of C_60 on the Si(100) Surface
- Study on Phase Transition of C_ through Fourier-Transform Infrared Spectroscopic Measurements
- Physicians' perspectives on "do-not-resuscitate" (DNR) orders
- Nurses' Perspectives concerning Do-Not-Resuscitate (DNR) Orders
- Elevated Concentration of Soluble Vascular Endothelial Cadherin Is Associated With Coronary Atherosclerosis
- Short-Term Therapy with Relatively Low-Dose Cerivastatin Improves Endothelial Function Independently of Its Lipid-lowering Effect : Evaluation of Brachial Artery Vasodilatation Using B-Mode Ultrasound Imaging
- Serum Hepatocyte Growth Factor Predicts Ventricular Remodeling Following Myocardial Infarction
- Assessment of Right and Left Ventricular Functions by TEI Index in Patients with Pericardial Effusion
- Increased soluble platelet/endothelial cell adhesion molecule-1 in the early stage of acute coronary syndrome
- Changes in plasma endothelin levels after administration of angiotensin II receptor blockers in patients with chronic heart failure
- Serum neopterin may predict progression of coronary atherosclerosis
- Age-Related Changes in Diastolic Atrioventricular Annular Velocity : Studies Using Pulsed Doppler Tissue Imaging
- PJ-391 Pentraxin 3, a Novel Inflammatory Marker, Predicts Left Ventricular Remodeling in Patients with Acute Myocardial Infarction(PJ066,ACS/AMI (Basic) (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
- Mitral Valve Prolapse Exhibiting Early Closure of the Aortic Valve and Protodiastolic Extrasound
- INFLUENCES OF VERAPAMIL AND MAGNESIUM SULFATE ON ISCHMIC MYOCARDIUM BY CORONARY SINUS RETROPERFUSION : EFFECTS ON ELECTROPHYSIOLOGICAL CHANGES DURING ACUTE MYOCARDIAL ISCHEMIA AND AFTER REPERFUSION
- FREQUENCY-DEPENDENT EFFECT OF MS-551, MEXILETINE, AND THEIR COMBINATION ON VENTRICULAR REFRACTORINESS
- Fabrication and Characterization of Peapod Field-Effect Transistors Using Peapods Synthesized Directly on Si Substrate
- Growth of mm-Long Carbon Nanotubes by Grid-Inserted Plasma-Enhanced Chemical Vapor Deposition
- Tunable Field-Effect Transistor Device with Metallofullerene Nanopeapods
- Fabrication Technique for Carbon Nanotube Single-Electron Transistors Using Focused Ion Beam
- Position-Controlled Carbon Nanotube Field-Effect Transistors Fabricated by Chemical Vapor Deposition Using Patterned Metal Catalyst
- Emphysematous Cystitis with Diabetic Neurogenic Bladder
- 0441 NONINVASIVE ASSESSMENT OF LEFT VENTRICULAR RELAXATION BY PULSED DOPPLER TISSUE IMAGING : COMPARISON WITH CARDIAC CATHETERIZATION
- -P138- INFLUENCE OF AGING ON LEFT ATRIAL APPENDAGE FLOW VELOCITY PATTERN IN HEALTHY SUBFECTS WITH SINUS RHYTHM : A STUDY WITH TRANSESOPHAGEAL PULSED DOPPLER ECHOCARDIOGRAPHY(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOC
- -0520- NONINVASIVE ASSESSMENT OF LEFT VENTRICULAR RELAXATION USING PULSED-WAVE DOPPLER LEFT VENTRICULAR INFLOW AND PULMONARY VENOUS FLOW VELOCITY CURVES(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- THE STUDY OF THE MECHANISMS OF MITRAL REGURGITATION AND ABNORMALITY OF MITRAL VALVE IN HYPERTROPHIC CARDIOMYOPATHY : COMPARISON WITH SIGMOID SEPTUM
- IV F12 The hippocampal kindling in Noda epileptic rat(NER)
- BE-O13 Construction of a novel detection system for protein-protein interactions using yeast G-protein signaling(Section V Biomolecular Engineering and Bioseparation)
- Clinical significance of anterior mitral leaflet fibrillation in patients with nonvalvular atrial fibrillation : comparison with blood flow and wall motion of the left atrial appendage
- Evaluation of Right Ventricular Function in Patients With Congestive Left Heart Failure by the Doppler Derived Total Cardiac Performance Index (TEI index)
- Synthesis, Structure, and Some Reactions of (2,4,6-Tri-t-butyl)thiobenzaldehyde, the First Stable Aromatic Thioaldehyde
- Evaluation of Right Ventricular Function in Patients With Complete Right Bundle-branch Block Using Total Cardiac Performance Index (TEI Index)
- Fibrinolytic Factors, Serum Lipid and C-reactive Protein Predicting Cardiac Events in Japanese Patients With Coronary Atherosclerotic Lesions
- Echocardiographic Assessment of Right Atrial Function in Patients With Myocardial Infarction With Reference to Obstructive Lesions of the Coronary Arteries
- -1002-EVALUATION OF PULMONARY VENOUS FLOW PATTERN IN PATIENTS WITH MITRAL VALVE DISEASE : A STUDY WITH TRANSESOPHAGEAL PULSED DOPPLER ECHOCARDIOGRAPHY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0369-A CLINICAL STUDY ON MITRAL VALVE PROLAPSE WITH THICKENED MITRAL LEAFLET (MYXOMATOUS DEGENERTION)
- INNERVATION OF THE MITRAL VALVE IN NORMAL AND MITRAL VALVE PROLAPSE : IMMUNOHISTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES : Valvular Heart Disease : 53 Annual Scientific Meeting, Japanese Circulation Society
- EVALUATION OF SHUNT AND PULMONARY VENOUS FLOW PATTERNS IN ATRIAL SEPTAL DEFECT : A STUDY WITH TRANSESOPHAGEAL PULSED AND COLOR DOPPLER ECHOCARDIOGRAPHY : Echocardiography, Pulsed Doppler : 53 Annual Scientific Meeting, Japanese Circulation Society
- -P92-CHARACTERISTICS ON LEFT VENTRICULAR EJECTION FLOW DYNAMICS IN PATIENTS WITH SIGMOID SEPTUM : WITH SPECIAL REFERENCE TO EJECTION SYSTOLIC MURMUR : Echocardiography, Pulsed Doppler : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC
- -82-ANALYSIS OF FLOW VELOCITY PATTERNS IN SUPERIOR VENA CAVA AND PULMONARY VEIN IN RELATION TO RIGHT AND LEFT VENTRICULAR DIASTOLIC PROPERTIES : Ventricular Function : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPAN
- Enrichment of Small-Diameter Double-Wall Carbon Nanotubes Synthesized by Catalyst-Supported Chemical Vapor Deposition Using Zeolite Supports
- Occurrence of Cobalamin Coenzymes in the Photosynthetic Green Alga, Chlorella vulgaris
- A Case of Thyrotoxicosis with Pancytopenia
- Pulmonary Venous Flow Velocity Patterns in Sinus Rhythm and Atrial Fibrillation : The Difference Between the Right and Left Pulmonary Veins
- PJ-627 Can Mitral Annular Velocity Predict Left Ventricular Remodeling after Acute Myocardial Infarction?(PJ105,Echo/Doppler (Others) 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-486 Intra- and Interatrial Dyssynchrony Determined by Tissue Doppler Imaging Predict the New-onset Atrial Fibrillation in Patients with Acute Myocardial Infarction(PJ082,Echo/Doppler (Myocardium) (I),Poster Session (Japanese),The 73rd Annual Scientific
- PJ-015 Preventive Effect of Renin-Angiotensin System Inhibitor on Left Atrial Remodeling in Patients with Chronic Atrial Fibrillation : Longterm Echocardiographic Study(PJ003,Atrial/Supraventricular Arrhythmia (Clinical/Diagnosis) (A),Poster Session (Japa
- FRS-100 Usefulness of Interatrial Dyssynchrony Determined by Tissue Doppler Imaging for Predicting the Transition from Nonvalvular Paroxysmal to Chronic Atrial Fibrillation(Leading Edge in Echocardiographic Technologies(2)(I),Featured Research Session,The
- PJ-363 Clinical Significance of Anterior Mitral Leaflet Fibrillation in Patients with Atrial Fibrillation : Comparison with Left Atrial Appendage Flow Velocity(Echo/Doppler-18, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-362 Prediction of Progression to Chronic Atrial Fibrillation in Elderly Patients With Nonvalvular Paroxysmal Atrial Fibrillation by Transthoracic Doppler Echocardiography(Echo/Doppler-18, The 71st Annual Scientific Meeting of the Japanese Circulation S
- OJ-222 Mitral Annulus Calcification in Patients with Aortic Valve Stenosis : Prevalence and Clinical Implications(Vascular heart disease/Pericarditis/Cardiac tumor-1 (H) OJ37,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of t
- QT-interval Dispersion in Type 2 Diabetic and No-diabetic Patients with Postmyocardial Infarction(Diabetes/Obesity 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-310 Changes in Plasma Adrenomedullin Levels after Administration of Angiotensin II Receptor Blockers in Patients with Chronic Heart Failure(Heart Failure, Clinical 6 (M) : PJ52)(Poster Session (Japanese))
- Effects of Atorvastatin Therapy on the Low-Density Lipoprotein Subfraction, Remnant-Like Particles Cholesterol, and Oxidized Low-Density Lipoprotein Within 2 Weeks in Hypercholesterolemic Patients
- Changes in Plasma lnterleukin-6 and CRP Levels after Administration of Angiotensin II Receptor Blockers in Patients with Chronic Heart Failure
- Effect of Age on Doppler TEI Index : Difference between the Left and the Right Heart
- Atrial Electrophysiologic Abnormalities in Patients with Wolff-Parkinson-White Syndrome Associated with No History of Atrial Fibrillation
- Contact Potential Measurement of Carbon Nanotube by Kelvin Probe Force Microscopy
- Effect of Molecular Forms on Distribution of Docosahexaenoic Acid into Organs in Mice
- Evaluation of Digestibility of Crude Fat and Digestible Energy on Soy Phosphatidylcholine〔和文〕
- X-Ray Emission Spectrum of Solid C_
- Rapid and Sensitive Method for Evaluation of Radical-Scavenging Activity Using Peroxyl Radicals Derived from 2,2'-Azobis(2-amidinopropane) Dihydrochloride Combined with Luminol Chemiluminescence
- Formation of Secondary Thin Carbon Nanotubes on Thick Ones and Improvement in Field-Emission Uniformity
- Bulk Plasmons in Solid C_
- Crystal Structure of C_ under High Pressure : Effect of Alloying
- Magnetic Susceptibility and X-Ray Diffraction Studies on the Growth and Disappearance Processes of the Superconducting Phase in C_K_x
- Survival Benefit of Screening for Early Esophageal Carcinoma in Head and Neck Cancer Patients
- Effect of Regurgitant jet Direction on Left Ventricular Diastolic Performance in Patients With Aortic Regurgitation
- Pseudonormalization of the TEI Index in Patients With Left Ventricular Systolic Dysfunction and Congestive Heart Failure
- Scanning Tunneling Microscopy/Spectroscopy of La_2@C_ Multilayer Islands on Si(100)-2×1-H Surfaces
- Observation of Highly Endoergic Chemiluminescent Reactions on Laser Ablation of Metals. Detection of A1H (A^1II), A1N (A^3II_i), A1O (B^2Σ^+) and MgO (B^1Σ^+) in A1 + NH_3, A1 + H_2O, and Mg + O_2 Systems
- CHANGES IN LEFT VENTRICULAR INFLOW AND PULMONARY VENOUS FLOW PATTERNS DURING LOWER BODY NEGATIVE AND POSITIVE PRESSURE IN HYPERTROPHIED HEART
- INFULUENCE OF PRELOAD INCREASE ON LEFT VENTRICULAR INFLOW VELOCITY PROFILE WITH RELAXATION FAILURE PATTERN IN VARIOUS HEART DISEASES
- LARGE V WAVE IN THE PULMONARY WEDGE PRESSURE TRACING : RELATION TO PULMONARY VENOUS FLOW AND LEFT VENTRICULAR INFLOW VELOCITY PATTERNS
- CHARACTERISTICS OF PULMONARY AND TRANSMITRAL FLOW VELOCITY PATTERNS AFTER CARDIOVERSION OF ATRIAL FIBRILLATION
- CLINICAL SIGNIFICANCE OF THE APICAL LATE-SYSTOLIC EJECTION MURMUR : NEW PHONOCARDIOGRAPHIC SIGN OF DYNAMIC OBSTRUCTION AT THE MID-PORTION OF THE LEFT VENTRICLE
- EVALUATION OF LEFT ATRIAL DIASTOLIC FUCTION BY RESPONSE OF PULMONARY VENOUS FLOW VELOCITY PATTERN DURING PRELOAD INCREASE IN DILATED HEARTS
- II G9 A case of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes(MELAS)with psychogenic pseudoseizures
- Production and Mass-Spectroscopic Characterization of Multiple Metal-Rich Alkali Halide Ion Clusters : Novel Structures and Properties
- Atomic Force Microscopy and Kelvin Probe Force Microscopy Measurements of Semiconductor Surface Using Carbon Nanotube Tip Fabricated by Electrophoresis
- AFM and KFM Measurements of Semiconductor Surface Using Carbon Nanotube Tip Fabricated by Electrophoresis
- Scanning Tunneling Microscopy of C_ on the Si(111)7 × 7 Surface
- Dose Dependency of a Parameter in Logistic Equation Simulating Survival Curves of Irradiated Aninals - III
- Production of Single-Wall Nanotubes by High-Temperature Pulsed Arc Discharge:Mechanisms of their Production
- Rate Correlation of Photoinduced Electron Transfer to C_
- EVALUATION OF RIGHT-TO-LEFT SHUNT IN ATRIAL SEPTAL DEFECT BY TRANSESOPHAGEAL CONTRAST ECHOCARDIOGRAPHY
- THE CLINICAL SIGNIFICANCE OF INTRAVENOUS AMRINONETO DIFFERENTIATE THE MECHANISM OF SECONDARY MITRAL REGURGITATION IN DILATED HEARTS
- PULMONARY VENOUS FLOW AND LEFT VENTRICULAR INFLOW VELOCITY PATTERNS BEFORE AND AFTER MITRAL VALVULOPLASTY IN PATIENTS WITH MITRAL CHORDAL RUPTURE
- Natural history of idiopathic mitral valve prolapse (MVP) with late-systolic murmur : Comparative study with MVP with only clicks and holo-systolic murmur
- Studies on the predisposing factor of severe mitral regurgitation in idiopathic mitral valve prolapse
- Structure and Morphology of Solid C_/C_ and C_ Grown from Benzene Solution
- Synthesis of Single- and Double-Wall Carbon Nanotubes by Gas Flow-Modified Catalyst-Supported Chemical Vapor Deposition
- Carbon K-Shell X-Ray Absorption Near-Edge Structure of Solid C_
- Crystal Structure of Buckminsterfullerene (C_) Incorporated by a U-Shaped Twin Donor
- Plasma and Platelet Plasminogen Activator Inhibitor-1 in Patients With Acute Myocardial Infarction
- Dose-response Relationship for Lifetime Excess Mortality and Temporal Pattern of Manifestation in Mice Irradiated Neonatally with Gamma Rays
- A novel Doppler echocardiographic score reflecting cardiac functional status can predict adverse outcome in acute myocardial infarction
- High E/e' disrupts the rapid lowering of blood glucose in response to exercise training