Effects of Atorvastatin Therapy on the Low-Density Lipoprotein Subfraction, Remnant-Like Particles Cholesterol, and Oxidized Low-Density Lipoprotein Within 2 Weeks in Hypercholesterolemic Patients
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概要
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The short- and intermediate-term pleiotropic effects of atorvastatin were investigated in 18 hypercholesterolemic patients, as well as the temporal differences in these pleiotropic effects. Atorvastatin was given for 3 months and fasting lipid concentrations, thiobarbituric acid reactive substances (TBARS), fibrinolytic parameters, and flow-mediated dilation of the brachial artery (FMD) were measured at baseline and after 2 weeks and 3 months of therapy. Atorvastatin reduced the total cholesterol (273±34 vs 188±31mg/dl, p<0.0001), low-density lipoprotein-cholesterol (LDL-C : 174±28 vs 111±23mg/dl, p<0.0001), small, dense LDL-C (34±22 vs 18±20%, p<0.01), remnant-like particles cholesterol (RLP-C : 8.8±6.0 vs 5.1±2.6mg/ml, p<0.01), and TBARS (3.3±1.0 vs 3.1±0.9nmol/ml, p<0.05) after 2 weeks. Atorvastatin decreased the concentration of small, dense LDL-C again after 3 months (8±13%, p<0.0001). The plasma concentrations of the fibrinolytic parameters did not change significantly after 3 months of atorvastatin therapy. FMD increased significantly after 2 weeks (5.6±2.1 vs 6.3±2.0%, p<0.01) and additionally increased after 3 months of therapy (8.3±1.9%, p<0.0001). There were no correlations between the pleiotropic effects and the improvement in the lipid profile. The results indicate some short-term pleiotropic effects of atorvastatin therapy within 2 weeks, which may be important with respect to the early benefits of statin therapy.
- 社団法人日本循環器学会の論文
- 2003-09-20
著者
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FUKUDA Nobuo
Department of Cardiology and Clinical Research, National Hospital Organization Zentsuji Hospital
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SAKABE Koichi
Department of Cardiology and Clinical Research, National Hospital Organization Zentsuji Hospital
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SHINOHARA Hisanori
Department of Cardiology and Clinical Research, National Hospital Organization Zentsuji Hospital
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TAMURA Yoshiyuki
Department of Cardiology and Clinical Research, National Hospital Organization Zentsuji Hospital
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Fnkuda Nobuo
Department Of Cardiology And Clinical Research National Hospital Organization Zentsuji Hospital
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Fukuda N
National Institute Of Radiological Sciences
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Fukuda Nobuo
Tsukuba Research Laboratory Nof Coproration
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Sakabe Koichi
Department Of Cardiology And Clinical Reseach National Hospital Organazation Zentsuji Hospital
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NADA Teru
Department of Cardiology and Clinical Research, National Zentsuji Hospital
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Nada Teru
Zentsuji National Hospital
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Sakabe Koichi
The Second Department Of Internal Medicine School Of Medicine The University Of Tokushirna
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WAKAYAMA Katsunori
Department of Cardiology and Clinical Research, National Hospital Organization Zentsuji Hospital
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Shinohara H
Department Of Cardiology And Clinical Research National Hospital Organization Zentsuji Hospital
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Tamura Yoshiyuki
Department Of Cardiology And Clinical Research National Hospital Organization Zentsuji Hospital
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Wakayama Katsunori
Department Of Cardiology And Clinical Research
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Shinohara Hisanori
Department Of Cardiology And Clinical Research National Hospital Organization Zentsuji Hospital
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Shinohara Hisanori
Department Of Internal Medicine And Clinical Research National Zentsuji Hospital
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Fukuda Nobuo
Department Of Internal Medicine And Clinical Research National Zentsuji Hospital
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Sakabe Kouichi
The Second Department Of Internal Medicine School Of Medicine The Univercity Of Tokushima
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Shinohara Hisanori
Department Of Cardiology And Clinical Research
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Sakabe Koichi
Department Of Cardiology And Clinical Research National Hoapital Organization Zentsuji Hospital
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