Increased Plasma Dipeptidyl Peptidase IV (DPP IV) Activity and Decreased DPP IV Activity of Visceral But Not Subcutaneous Adipose Tissue in Impaired Glucose Tolerance Rats Induced by High-Fat or High-Sucrose Diet(Miscellaneous)
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概要
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Several studies have investigated whether dipeptidyl peptidase IV (DPP IV) activity is correlated to the severity of diabetes; however, it remains unclear. To investigate the roles of DPP IV activity in metabolic abnormalities, impaired glucose tolerance rats were produced using a high-fat (HF) or high-sucrose (HS) diet. HF diet-fed rats obviously exhibited impaired glucose tolerance, with increases in subcutaneous and epididymal fat mass, insulin resistance and dyslipidaemia. In rats fed a HS diet rather than a normal diet, lower body weight and fasting blood glucose were observed temporarily in the early period after HS diet feeding; however, impaired glucose tolerance was evoked to some extent with an increase in epididymal fat mass. Both HF and HS diet-fed rats showed significantly higher plasma DPP IV activity than normal diet-fed rats, in the order of HF diet>HS diet>normal diet. HF and HS diets did not significantly affect DPP IV activity and mRNA expression in the kidney. On the other hand, HF, but not HS, diet caused a significant decrease in DPP IV activity in the liver as compared to the control. Of note, both HF and HS diets caused a significant decrease in DPP IV activity in epididymal fat, even though they did not change DPP IV activity in subcutaneous fat. In conclusion, HF or HS diet-induced impaired glucose tolerance with visceral fat accumulation may be interrelated with increased plasma DPP IV activity and decreased DPP IV activity of visceral but not subcutaneous adipose tissue.
- 公益社団法人日本薬学会の論文
- 2009-03-01
著者
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KAWAZOE Kazuyoshi
Department of Pharmacy, Tokushima University Hospital
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Minakuchi Kazuo
Department Of Radiology Osaka Prefectural Medical Center For Respiratory And Allergic Diseases
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SATO Youichi
Department of Human Genetics and Public Health, Faculty of Medicine, Graduate School of Proteomics,
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NAKAHORI Yutaka
Department of Human Genetics and Public Health, Faculty of Medicine, Graduate School of Proteomics,
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Sato Youichi
Department Of Electronics And Information Systems Engineering Hirosaki University
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Minakuchi Kazuo
Department Of Clinical Pharmacy Institute Of Health Biosciences The University Of Tokushima Graduate
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Nakahori Yutaka
Department Of Human Genetics And Public Health Institute Of Health Biosciences The University Of Tok
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Nakahori Yutaka
Department Of Human Genetics And Public Health Graduate School Of Medical Science The University Of
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Kawazoe Kazuyoshi
Department Of Clinical Pharmacy Institute Of Health Biosciences The University Of Tokushima Graduate
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KIRINO Yasushi
Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of T
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KAMIMOTO Takayuki
Department of Clinical Pharmacy, Institute of Health Biosciences, The University of Tokushima Gradua
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Kirino Yasushi
Department Of Human Genetics And Public Health Institute Of Health Biosciences The University Of Tok
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Kamimoto Takayuki
Department Of Clinical Pharmacy Institute Of Health Biosciences The University Of Tokushima Graduate
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Sato Youichi
Department Of Human Genetics And Public Health Institute Of Health Biosciences The University Of Tok
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Kawazof Kazuyoshi
Department of Clinical Pharmacy, Institute of Health Biosciences, The University of Tokushima Graduate School
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