Acute Leukemia of Ambiguous Lineage, Biphenotype, without CD34, TdT or TCR-rearrangement

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概要

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• Biphenotypic acute leukemia (BAL) is a rare entity that comprises 0.5-3% of all acute leukemias and probably arises from multipotent progenitor cells. The optimal approach for BAL therapy is unknown. Thus, it is important to elucidate the origin of the neoplastic cells for determination of the appropriate therapy. We report the case of a 41-year-old man with BAL having myeloid and T-lymphoid lineage phenotypes. Strangely, neither CD34 nor TdT expression nor rearrangement of TCR-α/β, δ/γ genes were shown. This pattern is rarely encountered and suggests that the blast cells were possibly considered immature with aspects of differentiation indicating myeloid lineage, rather than T-lymphoid lineage.

著者

• Tanaka Terukazu

  Environmental Health Sciences Faculty Of Medicine Kagawa University

• Ohnishi Hiroaki

  Division Of Hematology Department Of Internal Medicine Faculty Of Medicine Kagawa University

• Kubota Yoshitsugu

  Department Of Transfusion Medicine Faculty Of Medicine Kagawa University

• KITANAKA Akira

  Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki

• Ishida Toshihiko

  Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Japan

• Ishida Toshihiko

  Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University

• Waki Fusako

  Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University

• Kikuchi Fumi

  Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Japan

• Kikuchi Fumi

  Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University

• Nishiuchi Takamasa

  Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University

• Kamada Rie

  Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University

• Shintani Takamichi

  Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University

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