Leukemic Presentation of ALK-negative Anaplastic Large Cell Lymphoma in a Patient with Myelodysplastic Syndrome
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概要
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A 50-year-old woman with a history of aplastic anemia developed cervical lymphadenopathy and atypical lymphocytosis. Atypical cells of lymph nodes were positive for CD3 and CD30 but negative for anaplastic lymphoma kinase (ALK). Bone marrow examination showed trilineage myelodysplasia. She was diagnosed with ALK-negative anaplastic large cell lymphoma (ALCL) with leukemic transformation and myelodysplastic syndrome (MDS) which presumably developed from aplastic anemia. The lymphoma was resistant to intensive chemotherapies, ultimately leading to death. Leukemic presentation of ALK-negative ALCL as an initial manifestation is extremely rare, and the progression of the disease may be influenced by MDS through alteration of immune functions.
著者
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Nakaseko Chiaki
Department Of Clinical Cell Biology And Medicine Chiba University Graduate School Of Medicine
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Takagi Toshiyuki
Division Of Hematology And Chemotherapy Chiba Cancer Center Hospital
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Hashimoto Shinichiro
Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima
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Abe Daijiro
Department Of Hematology Oami Hospital
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Ohshima Koichi
Department Of Cell Pathology Graduate School Of Medical Sciences Kumamoto University
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Ohwada Chikako
Department Of Hematology Chiba University Hospital
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Tanaka Hiroaki
Department Of Biology Aichi University Of Education
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Takeda Yusuke
Department Of Hematology Chiba University Hospital
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Sakai Shio
Department Of Hematology Chiba University Hospital
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Takagi Toshiyuki
Division of Hematology-Oncology, Chiba Cancer Center Hospital, Japan
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Hashimoto Shinichiro
Department of Hematology, Oami Hospital, Japan
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Ohshima Koichi
Department of Pathology, School of Medicine, Kurume University, Japan
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Ohwada Chikako
Department of Hematology, Chiba University Hospital, Japan
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