L-Asparaginase-Induced Complete Response in a Relapsed Patient with Epstein-Barr Virus and Cytotoxic Peripheral T-Cell Lymphoma Not Otherwise Specified
スポンサーリンク
概要
- 論文の詳細を見る
We present a patient with Epstein-Barr virus (EBV)-positive cytotoxic peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) who was successfully treated using only L-asparaginase. A 46-year-old Japanese man was diagnosed with EBV-positive cytotoxic PTCL-NOS. Although he underwent chemotherapy using multiple agents, he relapsed with hemophagocytic syndrome. L-asparaginase treatment was initiated at 6,000 U/m2 on days 1, 3, 5, 10, and 12 together with prednisolone at 1 mg/kg. Although he developed grade 2 liver dysfunction and grade 2 coagulopathy, the patient achieved complete response status. Finally, he underwent allogeneic bone marrow stem cell transplantation, and he is currently still alive without disease at 24 months after the start of L-asparaginase therapy.
著者
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Tanaka Junko
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Araki Asuka
Department Of Pathology Organ Pathology Unit Shimane University School Of Medicine
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Maruyama Riruke
Department Of Laboratory Medicine And Central Clinical Laboratory Shimane Medical University
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Miyake Takaaki
Department Of Hematology Shimane University Faculty Of Medicine
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Kawakami Koshi
Department Of Hematology Shimane University Faculty Of Medicine
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Onishi Chie
Department Of Hematology Shimane University Faculty Of Medicine
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Ohshima Koichi
Department Of Cell Pathology Graduate School Of Medical Sciences Kumamoto University
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Takahashi Tsutomu
Department Of Dermatology Kobe University School Of Medicine
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Kawakami Koshi
Department of Hematology, Shimane University Hospital
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Ikejiri Fumiyoshi
Department of Hematology, Shimane University Hospital
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Inoue Masaya
Cancer Center, Shimane University Hospital
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Suzumiya Junji
Cancer Center, Shimane University Hospital
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Araki Asuka
Department of Pathology, Shimane University Hospital
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