Small Bowel Perforation Caused by Epstein-Barr Virus-Associated B Cell Lymphoma in a Patient with Angioimmunoblastic T-Cell Lymphoma
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概要
- 論文の詳細を見る
On rare occasions, secondary Epstein-Barr virus (EBV)-associated B cell lymphoma can develop in a patient with angioimmunoblastic T-cell lymphoma (AITL). We report a case of a 66-year-old Japanese woman who developed diffuse large B-cell lymphoma (DLBCL) in her small intestine after chemotherapy for AITL. She was found to have panperitonitis due to perforation of the small intestine. Partial ileectomy specimen showed DLBCL cells infiltrating into the intestinal wall. In situ hybridization for EBV-encoded RNA revealed positivity in the lymphoma cells. The lymph nodes diagnosed as AITL were negative for EBV infection and there was no coexistence of B cell neoplasms in them. We thought small bowel perforation in this case was caused by EBV-associated B cell lymphoma secondary to AITL. Our case showed a remarkable deficiency of cellular immunity after chemotherapy, which we postulate was related to the cause of occurrence of B-cell lymphoma. [J Clin Exp Hematopathol 50(1) : 59-63, 2010]
- 2010-05-01
著者
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TANAKA Junko
Department of Medicine, Kidney Center, Tokyo Women's Medical University
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TAKAHASHI Tsutomu
Department of Hematology, Shimane University Faculty of Medicine
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MARUYAMA Riruke
Department of Organ Pathology, Shimane University Faculty of Medicine
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MISHIMA Satoko
Department of Functional Pathology, Shimane University Faculty of Medicine
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INOUE Masaya
Division of Clinical Study of Oncology, Shimane University Hospital
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KAWAKAMI Koshi
Department of Hematology, Shimane University Faculty of Medicine
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ONISHI Chie
Department of Hematology, Shimane University Faculty of Medicine
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MIYAKE Takaaki
Department of Hematology, Shimane University Faculty of Medicine
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NABIKA Toru
Department of Functional Pathology, Shimane University Faculty of Medicine
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ISHIKURA Hiroto
Division of Clinical Study of Oncology, Shimane University Hospital
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Nabika Toru
Department Of Functiona Pathology Shimane University School Of Medicine
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Nabika Toru
Department Of Functional Pathology Shimane University Faculty Of Medicine
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Tanaka Junko
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Maruyama Riruke
Department Of Organ Pathology Shimane University Faculty Of Medicine
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Maruyama Riruke
Department Of Laboratory Medicine And Central Clinical Laboratory Shimane Medical University
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Miyake Takaaki
Department Of Hematology Shimane University Faculty Of Medicine
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Ishikura Hiroto
Division Of Clinical Study Of Oncology Shimane University Hospital
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Inoue Masaya
Division Of Clinical Study Of Oncology Shimane University Hospital
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Mishima Satoko
Department Of Functional Pathology Shimane University Faculty Of Medicine
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Kawakami Koshi
Department Of Hematology Shimane University Faculty Of Medicine
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川上 耕史
Department Of Internal Medicine Tsuwano Kyozon Hospital
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Onishi Chie
Department Of Hematology Shimane University Faculty Of Medicine
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Tanaka Junko
Department Of Hematology Shimane University Faculty Of Medicine
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Takahashi Tsutomu
Department Of Food And Nutrition Konan Women's College
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Takahashi Tsutomu
Department Of Hematology Shimane University Faculty Of Medicine
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Takahashi Tsutomu
Department Of Dermatology Kobe University School Of Medicine
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KAWAKAMI Koshi
Department of Applied Chemistry (Course of Materials Chemistry), Graduate School of Engineering, Osaka University
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