Oncogene Associated cDNA Microarray Analysis Shows PRAME Gene Expression is a Marker for Response to Anthracycline Containing Chemotherapy in Patients with Diffuse Large B-cell Lymphoma

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概要

• 論文の詳細を見る

• CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) therapy achieves a response in more than 60% patients with diffuse large B-cell lymphomas (DLBCLs). However, DLBCL shows a heterogeneous response to chemotherapy, and some patients are refractory to CHOP therapy. This difference in response to therapy is most likely due to differences in biological characteristics. We used cDNA microarray analysis to identify genes differentially expressed in anthracycline containing chemotherapy-resistant DLBCLs (7 patients) compared with anthracycline containing chemotherapy-sensitive DLBCLs (6 patients). Nine genes on the cDNA chip showed increased expression in anthracycline containing chemotherapy-resistant patients. We chose the preferentially expressed antigen of melanoma (PRAME) gene because it showed the highest expression in anthracycline containing chemotherapy-resistant DLBCLs on the cDNA chip, and it has been linked to prognosis of hematological malignancies. We also examined the relationship between PRAME gene expression and progression-free survival (PFS) in 45 patients with DLBCL. The progression-free survival of PRAME-positive patients (n=12) was significantly worse than that of PRAME-negative patients (n=33) (p=0.0373). Our results therefore indicate that PRAME expression in DLBCL correlates with response to anthracycline containing chemotherapy. [J Clin Exp Hematopathol 49(1) : 1-7, 2009]

• 日本リンパ網内系学会の論文
• 2009-05-01

著者

• OHSHIMA Koichi

  Department of Pathology, Kurume University School of Medicine

• UIKE Naokuni

  Department of Hematology, National Kyushu Cancer Center

• ETO Tetsuya

  Department of Hematology, Hamanomachi Hospital

• SUZUMIYA Junji

  Department of Internal Medicine, Fukuoka University Chikushi Hospital

• Tamura Kazuo

  First Department of Internal Medicine, Fukuoka University

• KIKUCHI Masahiro

  Department of Pathology, School of Medicine, Fukuoka University

• Osaki Koichi

  九州厚生年金病院

• Muta K

  Department Of Pathology School Of Medicine Fukuoka University

• Ohshima K

  Department Of Pathology Kurume University School Of Medicine

• TAKESHITA Morishige

  Department of Pathology, Fukuoka University School of Medicine

• SUZUMIYA Junji

  First Department of Internal Medicine, School of Medicine, Fukuoka University

• Usubuchi Noriko

  国立がんセンター中央病院

• Suzumiya J

  Department Of Internal Medicine Fukuoka University Chikushi Hospital

• Suzumiya Junji

  福岡大学 医学部内科学第一

• Suzumiya Junji

  福岡大学病院 病理部

• Suzumiya Junji

  Department Of Internal Medicine Fukuoka University

• Uike Naokuni

  National Kyushu Cancer Center Fukuoka Jpn

• Takeshita Morishige

  Department Of Pathology School Of Medicine Fukuoka University

• KARUBE Kennosuke

  Department of Pathology, School of Medicine, Kurume University

• KIKUCHI Masahiro

  Murakami Karindoh Hospital

• Usui N

  Division Of Hematology And Oncology Department Of Medicine Jikei University

• Ohnishi K

  Third Department Of Internal Medicine Hamamatsu University School Of Medicine

• Ohnishi Kazunori

  東北大学病院 血液･免疫科

• Eto T

  Department Of Hematology Hamanomachi Hospital

• Etoh Tetsuya

  国立がんセンター中央病院

• Tamura Kazuo

  Division Of Medical Oncology And Hematology Department Of Medicine Fukuoka University Hospital

• Usui N

  Jikei University Hospital

• Oshima Koichi

  Division Of Hematology Department Of Medicine Kurume University School Of Medicine

• Kikuchi M

  Murakami Karindoh Hospital

• Kikuchi Masahiro

  福岡大学 医学部内科学第一

• Karube Kennosuke

  Department Of Pathology School Of Medicine Kurume University

• Karube Kennosuke

  Department Of Pathology Kurume University School Of Medicine

• Uike Naokuni

  Department Of Hemato-oncology Kyushu Cancer Center

• Kume Masaaki

  Division Of Hematology And Oncology Department Of Medicine Akita University School Of Medicine

• Tamura Kazuo

  First Department Of Internal Medicine School Of Medicine Fukuoka University

• Eto Tetsuya

  Hamanomachi General Hospital Fukuoka Jpn

• Ohshima Koichi

  First Department Of Pathology Fukuoka University

• Ohshima Koichi

  First Department Of Pathology Fukuoka University School Of Medicine

• Suzumiya Junji

  Division Of Oncology Hematology And Infectious Diseases Department Of Medicine Fukuoka University Sc

• Suzumiya Junji

  First Department Of Internal Medicine School Of Medicine Fukuoka University

• Suzumiya Junji

  Department Of Internal Medicine I School Of Medicine Fukuoka University

• KAWANO Riko

  First Department of Internal Medicine, School of Medicine, Fukuoka University

• Eto Tetsuya

  Department Of Hematology Hamanomachi Hospital

• Kikuchi Masahiro

  Department Of Internal Medicine National Miyakonojo Hospital

• Ohnishi Kazunori

  Third Department Of Internal Medicine Hamamatsu University School Of Medicine

• Takeshita Morishige

  Department Of Pathology School Of Medicine Kurume University

• Kamimura Tomohiko

  Department Of Hematology Harasanshin General Hospital

• Ohnishi Kazunori

  Department Of Internal Medicine Hamamatsu University School Of Medicine

• Omachi Ken

  Department Of Hematology And Oncology Tokai University School Of Medicine

• Kawano Riko

  First Department Of Internal Medicine School Of Medicine Fukuoka University

• Ochi Kensuke

  Laboratory Of Molecular Medicine Human Genome Center Institute Of Medical Science University Of Toky

• Kikuchi Masahiro

  Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine

• Kojima Masaru

  Department Of Anatomic And Diagnostic Pathology Dokkyo Medical University

• Ohashi K

  Third Department Of Internal Medicine Hamamatsu University School Of Medicine

• Tamura Kazuo

  Institute For Advanced Medical Sciences Hyogo College Of Medicine

• Takeshita Morishige

  The Department Of Pathology National Kyushu Medical Center

• Takeshita Morishige

  Department Of Pathology Faculty Of Medicine Fukuoka University

• Ohshima Koichi

  Department Of First Pathology Fukuoka University

• Tamura Kazuo

  First Department Of Internal Medicine School Of Medicine Fkuoka University

• Ohshima Koichi

  Department Of Cell Pathology Graduate School Of Medical Sciences Kumamoto University

• Tamura Kazuo

  The Department Of Medicine Division Of Medical Oncology Infectious Disease And Endocrinology School

• Takeshita Morishige

  Department Of Cell Pathology Graduate School Of Medical Sciences Kumamoto University

• Takeshita Morishige

  Departments Of Pathology Faculty Of Medicine Fukuoka University; Fukuoka Japan

• Uike Naokuni

  Department Of Hematology National Organization Kyushu Cancer Center; Fukuoka Japan

• Tamura Kazuo

  First Department Of Internal Medicine Fukuoka University

• Tamura Kazuo

  Department Of Internal Medicine Fukuoka University

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