Cladribine Treatment in Two-Hour Intravenous Infusion for Previously-Treated Low Grade B-Cell Lymphoma : A Pilot Study

元データ 2009-11-01 日本リンパ網内系学会

概要

Cladribine is approved to be used in 24-hour continuous infusion for the treatment of low-grade lymphoma by the Ministry of Health, Labor and Welfare in Japan. Pharmacokinetic studies showed that the antitumor activity of cladribine by 2-hour infusion should be comparable to that given by continuous infusion. The safety and anti-tumor activity of short infusion of cladribine was shown in hairy cell leukemia, chronic lymphocytic leukemia and low-grade non-Hodgkins lymphoma in Europe. We therefore underwent a pilot study to confirm the safety and efficacy of cladribine given by 2-hour infusion for Japanese patients with relapsed or refractory indolent B-cell lymphoma. Cladribine at a dose of 0.09 mg/kg was administered in 2-hour intravenous infusion for 5 consecutive days. The treatment was repeated at a 28-day interval for at least 2 cycles, and its efficacy and toxicity were investigated. Fourteen patients were entered into this study. Eight patients (57%) responded to cladribine, including 2 (14%) complete response (CR) and 6 (43%) partial response (PR). The median duration of response was 20+ and 21+ months for CR, and 12 months ranging from 3 to 34 months for PR, respectively. Grade 3 or 4 neutropenia and lymphocytopenia occurred in 43% and 71% of patients, respectively, but there was no febrile neutropenia or opportunistic infection associated with cladribine treatment. No other adverse events greater than grade 3 were encountered. The tumor response and degree of toxicity were comparable with those observed in cladribine treatment given by continuous infusion at a same dose. Cladribine can be administered in 2-hour infusion in an outpatient clinic and is therefore quite convenient for patients. [J Clin Exp Hematopathol 49(2) : 69-75, 2009]

著者

TAMURA Kazuo Division of Medical Oncology and Hematology, Department of Medicine, Fukuoka University Hospital
SUZUMIYA Junji Department of Internal Medicine, Fukuoka University Chikushi Hospital
Ogata Kentaro Faculty of Pharmaceutical Sciences, Fukuoka University
SUZUMIYA Junji Division of Oncology, Hematology, and Infectious Diseases, Department of Medicine, Fukuoka Universit
TAKAMATSU Yasushi Division of Oncology, Hematology, and Infectious Diseases, Department of Medicine, Fukuoka Universit
Suzumiya J Department Of Internal Medicine Fukuoka University Chikushi Hospital
Suzumiya Junji 福岡大学 医学部内科学第一
Suzumiya Junji 福岡大学病院 病理部
Suzumiya Junji Department Of Internal Medicine Fukuoka University
Tamura Kazuo Division Of Medical Oncology And Hematology Department Of Medicine Fukuoka University Hospital
Takamatsu Y Medicine And Biosystemic Science Kyushu University Graduate School Of Medical Sciences
Suzumiya Junji Division Of Oncology Hematology And Infectious Diseases Department Of Medicine Fukuoka University Sc
Suzumiya Junji Department Of Internal Medicine I School Of Medicine Fukuoka University
Ogata Kentaro Faculty Of Pharmaceutical Sciences Fukuoka University
Ogata Kentaro Department Of Neuropathology Tokyo Metropolitan Institute For Neuroscience
Ogata Kentaro Department Of Laboratory Medicine Kawasaki Municipal Ida Hospital
KATAYOSE Keiko Division of Medical Oncology, Hematology and Infectious Disease, Department of Medicine, Fukuoka Uni
SASAKI Hidenori Division of Medical Oncology, Hematology and Infectious Disease, Department of Medicine, Fukuoka Uni
ISHITSUKA Kenji Division of Medical Oncology, Hematology and Infectious Disease, Department of Medicine, Fukuoka Uni
KIMURA Nobuhiro Division of Medical Oncology, Hematology and Infectious Disease, Department of Medicine, Fukuoka Uni
Yoshida Takashi Department Of Hematology Japanese Red Cross Nagoya First Hospital
Kimura Nobuhiro Division Of Medical Oncology Hematology And Infectious Disease Department Of Medicine Fukuoka Univer
Kamimura Tomohiko Department Of Hematology Harasanshin General Hospital
Katayose Keiko Division Of Medical Oncology Hematology And Infectious Disease Department Of Medicine Fukuoka Univer
Takamatsu Yasushi Division Of Medical Oncology Hematology And Infectious Disease Department Of Medicine Fukouka Univer
Sasaki Hidenori The Department Of Medicine Division Of Medical Oncology Infectious Disease And Endocrinology School
Ishitsuka Kenji The Department Of Medicine Division Of Medical Oncology Infectious Disease And Endocrinology School
Tamura Kazuo Institute For Advanced Medical Sciences Hyogo College Of Medicine
Sasaki Hidenori Division Of Medical Oncology Hematology And Infectious Disease Fukuoka University
Ishitsuka Kenji Division Of Medical Oncology Hematology And Infectious Disease Fukuoka University
Tamura Kazuo The Department Of Medicine Division Of Medical Oncology Infectious Disease And Endocrinology School
Ishitsuka Kenji Division Of Medical Oncology Hematology And Infectious Disease Department Of Internal Medicine Fukuoka University
Tamura Kazuo First Department Of Internal Medicine Fukuoka University
Tamura Kazuo Department Of Internal Medicine Fukuoka University

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