Sweet's Syndrome Complicated by Kikuchi's Disease and Hemophagocytic Syndrome which Presented with Retinoic Acid-inducible Gene-I in both the Skin Epidermal Basal Layer and the Cervical Lymph Nodes
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概要
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A 21-year-old man was admitted to our hospital with a fever, erythema, cervical lymphadenopathy and pancytopenia. A diagnosis of Sweet's syndrome (SS) with Kikuchi's disease (KD) and hemophagocytic syndrome (HPS) was made based on the results of a bone marrow aspiration along with the results from biopsy specimens of the brachial skin and a cervical lymph node. The expression of retinoic acid-inducible gene-I (RIG-I) in the skin epidermal basal layer as well as in a cervical lymph node was revealed through immunohistochemistry. He successfully entered remission through treatment with prednisolone. This findings of this case indicate that when SS with KD presents as HPS, it may suggest an association with an RIG-I-related innate immunity.
著者
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Yamasaki Satoshi
Unit Of Translational Medicine Department Of Immunology And Rheumatology Graduate School Of Biomedic
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Nakamura Hideki
Unit Of Translational Medicine Department Of Immunology And Rheumatology Graduate School Of Biomedic
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Kawakami Atsushi
Unit Of Translational Medicine Department Of Immunology And Rheumatology Graduate School Of Biomedic
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Ohshima Koichi
Department Of Cell Pathology Graduate School Of Medical Sciences Kumamoto University
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MIZOKAMI Akinari
Department of Internal Medicine, Nagasaki Municipal Hospital
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Koga Tomohiro
Unit Of Translational Medicine Department Of Immunology And Rheumatology Graduate School Of Biomedic
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Horai Yoshiro
Unit Of Translational Medicine Department Of Immunology And Rheumatology Nagasaki University
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Takano Kanako
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Japan
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Kawakami Atsushi
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Japan
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Mizokami Akinari
Department of Rheumatology, Nagasaki Municipal Hospital, Japan
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Ohshima Koichi
Department of Pathology, Kurume University School of Medicine, Japan
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Nakamura Hideki
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Japan
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