Effect of nifedipine, dilazep, dinitrates and propranolol on blood lactate accumulation during intensive graded exercise testing in healthy young subjects.

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概要

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• The aim of the present study was to elucidate the effects of 4 different cardiovascular drugs on blood lactate levels during an intensive graded exercise test in 17 healthy male subjects. In acute studies, isosorbide dinitrate and nifedipine were used. In chronic studies, propranolol dihydrochloride and dilazep dihydrochloride were used. Oxygen uptake (_V_o2), heart rate, blood pressure and blood lactate were measured at rest and during the final minute of each exercise session. Hemodynamic measurements during submaximum exercise were influenced by all drugs except isosorbide dinitrate. _V_o2 during submaximum and maximum exercises remained unchanged by all drug treatments. Blood lactate levels at rest and during submaximum and maximum exercise also did not change significantly. Work load corresponding to blood lactate concentration of 4mM (W4mM) and the 1st and 2nd break points of lactic acid (WBPLA1 and WBPLA2) were almost the same in all treatments. It is concluded that the 3 criteria of blood lactate obtained during the graded exercise test are not affected by these drugs in healthy males

• International Heart Journal刊行会の論文

著者

• SHINDO Munehiro

  Department of Exercise Physiology, School of Physical Education, Fukuoka University

• Shindo Munehiro

  Department Of Exercise Physiology School Of Physical Education Fukuoka University

• Arakawa Kikuo

  Second Department Of Internal Medicine

• Kumagai Shuzo

  Department Of Community Health Science Saga Medical School

• Hiroki Tadayuki

  Second Department of Internal Medicine, Fukuoka University School of Medicine

• YOSHIDA Toyokazu

  Second Department of Internal Medicine, Fukuoka University School of Medicine

• Tanaka Hiroaki

  Department Of Biology Aichi University Of Education

• MUTAGUCHI Takashi

  Second Department of Internal Medicine, School of Medicine, Fukuoka University

• MORIYAMA Yoshihiro

  Second Department of Internal Medicine, School of Medicine, Fukuoka University

• YOSHIDA Toyokazu

  Second Department of Internal Medicine, School of Medicine, Fukuoka University

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