Reduction in Serum Total Cholesterol and Risks of Coronary Events and Cerebral Infarction in Japanese Men : The Kyushu Lipid Intervention Study
スポンサーリンク
概要
- 論文の詳細を見る
Lowering serum total cholesterol is shown to decrease the risk of coronary heart disease (CHD) in Western countries, but evidence is limited regarding cerebral infarction (CI). The present study used the Kyushu Lipid Intervention Study to examine the risks of CHD events and CI in relation to reduction in serum total cholesterol. Subjects were 4,615 men aged 45-74 years with serum total cholesterol of 220mg/dl (5.68mmol/L) or greater who had no history of CHD events or stroke. CHD events and CI numbered 125 and 92, respectively, in a 5-year follow-up. After adjustment for potential confounding factors, the relative risks of CHD events and CI for 15% or greater reduction in total cholesterol, compared with less than 5% reduction, were 0.78 (95% confidence limit [CL] 0.46-1.32) and 0.39 (95% CL 0.22-0.69), respectively. As compared with on-treatment cholesterol levels of 240 mg/dl (6.20 mmol/L) or higher, the risk of CHD events was approximately 50% lower across 3 categories below 240mg/dl (6.20mmol/L), and that of CI was 70% lower at 2 categories below 220mg/dl (5.68mmol/L). Lowering serum total cholesterol below 220mg/dl (5.68mmol/L) seems desirable with regard to the prevention of CI. (Circ J 2003; 67: 473-478)
- 社団法人日本循環器学会の論文
- 2003-05-20
著者
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KONO Suminori
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University
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Kono Suminori
Department Of Preventive Medicine Kyushu University Faculty Of Medical Sciences
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SASAKI Jun
Graduate School of Clinical Trial Management, International University of Health and Welfare
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IWASHITA Mikio
Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences
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Sasaki Jun
Second Department of Internal Medicine, Fukuoka University School of Medicine
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Arakawa Kikuo
Second Department of Internal Medicine, Fukuoka University School of Medicine
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Matsushita Yasuyuki
Departments of Postmarketing Surveillance and Regulatory Affairs, Sankyo Company Limited
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Iwashita Mikio
Department Of Preventive Medicine Kyushu University Faculty Of Medical Sciences
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Arakawa Kikuo
Kyushu Lipid Intervention Study (klis) Group:the Second Department Of Internal Medicine Fukuoka Univ
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Sasaki Jun
Graduate School Of Clinical Trial Management International University Of Health And Welfare
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Arakawa Kikuo
Second Department Of Internal Medicine
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Kono Suminori
Department Of Preventive Medicine Facculty Of Medical Sciences Kyushu University
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Matsushita Yasuyuki
Kyushu Lipid Intervention Study (klis) Group:departments Of Postmarketing Surveillance And Regulator
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Kono Suminori
Department Of Medicine And Bioregulatory Science Graduate School Of Medical Sciences Kyushu Universi
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Sasaki Jun
Second Department Of Internal Medicine Fukuoka University Hospital
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Matsushita Yasuyuki
Department of Clinical Pharmacology and Biostatistics, Sankyo Company Limited
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