Analysis of the exercise-induced orthogonal P wave changes in normal subjects and patients with coronary artery disease.

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概要

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• Near-maximal treadmill exercise testing was performed on 26 normal individuals (NL) and 78 patients with coronary artery disease (CAD) using a modified Bruce's protocol. Exercise-induced changes in orthogonal P wave measurements were made automatically, using an averaging technique, immediately before and 30sec after treadmill exercise to assess their diagnostic significance in evaluation of left ventricular (LV) function in CAD patients. The maximal inferior and posterior components of the P wave and the maximal P-vector magnitude in the frontal and left sagittal planes showed a statistically significant increase after treadmill exercise both in NL and CAD patients. These changes were considered to be physiological responses of the P wave to dynamic exercise. The percent changes of the maximal horizontal P-vector magnitude (%Hmax) were significantly higher after treadmill exercise in CAD patients than in NL. In patients with effort angina pectoris and without a previous myocardial infarction, the %Hmax showed a highly significant negative correlation with the percent changes of the LV ejection fraction (r=0.66, p<0.01), measured by exercise RI angiography. These results suggest that the exercise-induced increase in %Hmax reflects transient impairment of LV function during exercise. It was concluded that a %Hmax of more than 120% provided a useful, noninvasive index for assessing LV function in treadmill exercise testing.

• International Heart Journal刊行会の論文

著者

• KOIDE MASAFUMI

  First Department of Internal Medicine, Nagoya University School of Medicine

• Noda Shoji

  First Department of Internal Medicine, Nagoya University School of Medicine

• Sotobata Iwao

  First Dep. Of Intern. Med. Nagoya Univ.

• Kawai Naoki

  First Dep. Of Intern. Med. Nagoya Univ.

• Koide Masafumi

  First Department Of Internal Medicine Nagoya University School Of Medicine:department Of Laboratory

• Yoshida Reiki

  First Department Of Internal Medicine Nagoya University School Of Medicine

• Yokota Mitsuhiro

  First Department Of Internal Medicine Nagoya University School Of Medicine

• Hayashi Hiroshi

  First Department Of Internal Medicine Nagoya University School Of Medicine

• MOCHIZUKI Kazuo

  First Department of Internal Medicine, Nagoya University School of Medicine

• NODA Shoji

  First Department of Internal Medicine

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