Influences of the Alteration in Aortic Pressure on Regional Myocardial Function and Regional Myocardial Blood Flow in Partial Coronary Artery Occlusion

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This study was designed to simultaneously evaluate the effects of alterations in aortic pressure (AoP) on regional myocardial function and regional myocardial blood flow (MBF) in anesthetized dogs with partial coronary occlusion. Regional myocardial function was assessed by both segment-length and tension gauges. The left circumflex coronary artery flow was reduced to 50 to 70% by a constrictor. When systolic aortic pressure (AoPS) fell from 103.6±7.4 to 72.5±4.9mmHg following nitroprusside infusion, systolic shortening (SS) markedly depressed from 0.63±0.17 to 0.09±0.20mm (p<0.01), developed tension (DT) decreased by 30% (p<0.01), and MBF assessed with tracer microspheres decreased from 0.61±0.13 to 0.36±0.11ml/min/Gm (p<0.01) in ischemic regions. In non-ischemic regions SS was enhanced from 0.78±0.16 to 0.89±0.15mm (p<0.05), but DT and MBF showed no changes. An elevation of AoPS from 106.4±5.6 to 143.3±6.9mmHg following methoxamine infusion brought about enhanced SS from 0.42±0.15 to 0.48±0.09mm (p<0.05), a 50%-increase in DT (p<0.01), and was associated with an increase in MBF from 0.66±0.03 to 1.19±0.07ml/min/Gm (p<0.01) in ischemic regions.These results indicate that, in partial coronary occlusion, a fall of AoP induces redistribution of blood flow away from ischemic regions and aggravates the function of the ischemic myocardium, while an elevation of AoP may produce beneficial effects upon the ischemic myocardium.
International Heart Journal刊行会の論文

Influences of the Alteration in Aortic Pressure on Regional Myocardial Function and Regional Myocardial Blood Flow in Partial Coronary Artery Occlusion

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