NOVEL PHORBOL ANALOGS WHICH BIND TO PROTEIN KINASE C (PKC) WITHOUT ACTIVATION

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概要

• 論文の詳細を見る

• 13-Deacetoxy-11-demethyl-phorbol derivatives with acyl groups of various lengths (from hexanoyl to tetradecanoyl) at the C-12 position were synthesized in an optically active from. Although considerable binding affinities to PKC were observed by analogs 3-7,no activation of PKC was seen even at 10 μM.

• 公益社団法人日本薬学会の論文
• 1996-02-15

著者

• 柴崎 正勝

  東大 大学院

• Sawada Daisuke

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Sodeoka Mikiko

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• SUGITA Kazuyuki

  Graduate School of Science and Technology, Chiba University

• Sasai Hiroaki

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Sugita K

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• SUGITA Kazuyuki

  Faculty of Pharmaceutical Sciences, University of Tokyo

• SHIBASAKI Masakatsu

  Faculty of Pharmaceutical Sciences, University of Tokyo

• Shibasaki Masakatsu

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Shibasaki Masakatsu

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

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