Synthesis and Biological Evaluation of 4-Substituted Vitamin D and 14-Epi-Previtamin D Analogs
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概要
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We synthesized the 4-hydroxy and 4-methoxy analogs of active vitamin D3 (1α,25(OH)2D3, 1) and its C14-epimer with the previtamin D3 form of 14-epi-1α,25(OH)2preD3 (14-epi-pre1). Their vitamin D receptor (VDR) binding affinity and osteocalcin promoter transactivation activity in HOS cells were evaluated, and had lower activity than the natural hormone (1) and 14-epi-pre1, respectively.
著者
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Sawada Daisuke
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Kittaka Atsushi
Faculty Of Pharmaceutical Sciences Teikyo University
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Takenouchi Kazuya
Teijin Institute for Bio-medical Research, Teijin Pharma Ltd.
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Tsukuda Yuya
Faculty of Pharmaceutical Sciences, Teikyo University
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Saito Hiroshi
Teijin Institute for Bio-medical Research, Teijin Pharma Ltd.
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Takagi Ken-ichiro
Teijin Institute for Bio-medical Research, Teijin Pharma Ltd.
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Ochiai Eiji
Teijin Institute for Bio-medical Research, Teijin Pharma Ltd.
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Horie Kyouhei
Teijin Institute for Bio-medical Research, Teijin Pharma Ltd.
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