Coronary Artery Spasm and the Polymorphisms of the Endothelial Nitric Oxide Synthase Gene
スポンサーリンク
概要
- 論文の詳細を見る
Background Coronary artery spasm plays an important role in the pathogenesis of vasospastic angina, and contributes to the development of several acute coronary syndromes. Endothelial nitric oxide synthase (ecNOS) catalyzes the synthesis of nitric oxide, which regulates vascular tone, and may be related to coronary vasospasm. The present study investigated whether coronary spasm is related to particular polymorphisms of the ecNOS gene. Methods and Results Spasm provocation by serial infusions of acetylcholine was performed on 165 patients who were clinically suspected of having angina. In both study patients and healthy controls (n=400), genomic polymorphisms of the ecNOS gene were determined by using polymerase chain reaction. Quantitative luminal diameter measurements of the 3 major coronary arteries were initially obtained before and after acetylcholine injection, and then after isosorbide dinitrate injection, by using a computer-assisted analysis system. Logistic multiple regression analysis identified the a/a or a/b genotype in intron 4 of ecNOS (NOS4a: p=0.0431, odds ratio (OR) 2.43) and diabetes mellitus (p=0.0060, OR 4.88) as significant predictors of coronary spasm. In the patients with NOS4a, both the induced and spontaneous contractions were augmented. Conclusion The present study results indicated that NOS4a could be a good marker for coronary artery spasm.
- 社団法人日本循環器学会の論文
- 2006-03-20
著者
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OHNO Minoru
Department of Cardiovascular Center, Toranomon Hospital
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AIZAWA Tadanori
The Cardiovascular Institute, Graduate School of Health Sciences Tokyo Medical and Dental University
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Ogasawara Ken
The Cardiovascular Institute
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Kaneda Hideaki
Department of Cardiology
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Aizawa Tadanori
The Cardiovascular Institute
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TAGUCHI Junichi
Department of Cardiology, Tokai University Hachioji Hospital
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Aizawa Toru
Department Of Cardiovascular Medicine The University Of Tokyo
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KUWADA Yukihiro
Department of Cardiovascular Medicine, Faculty of Medicine University of Tokyo
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Aizawa Toru
Department Of Aging Medicine And Geriatrics Shinshu University School Of Medicine
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Ohno Minoru
Department Of Cardiovascular Medicine The University Of Tokyo
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Ohno Minoru
Department Of Cardiology Toranomon Hospital
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Oono Minoru
Department Of Cardiovascular Medicine Toranomon Hospital
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Ohno Minoru
Department Of Cardiovascular Center Toranomon Hospital
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Kaneda Hideaki
Department Of Cardiovascular Medicine The University Of Tokyo
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Aizawa Tadanori
Department Of Cardiology The Cardiovascular Institute
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Aizawa Tadanori
Cardiovascular Institute
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Aizawa Tadanori
The Cardiovascular Institute Nippon Medical School
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YAMAKADO Minoru
Mitsui Memorial Hospital, Department of Health Care
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Ogasawara Ken
The Cardiovascular Institute Hospital
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Hangaishi Misako
Department of Cardiovascular Medicine, The University of Tokyo
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Kuwada Yukihiro
Department Of Cardiovascular Medicine The University Of Tokyo
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Kuwada Yukihiro
Department Of Cardiovascular Medicine Faculty Of Medicine University Of Tokyo
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Taguti Jun-ichi
Department Of Cardiology Hachioji Hospital Tokai University
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Taguchi Junichi
Department Of Cardiology Tokai University Hachioji Hospital
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Aizawa Toru
Department Of Cardiovascular Medicine University Of Tokyo Graduate School Of Medicine
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Ohno Minoru
Department Of Cardiovascular Medicine Toranomon Hospital
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Oono Minoru
Departments Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Yamakado Minoru
Mitsui Memorial Hospital
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Ohno Minoru
Department Of Cardiovascular Medicine University Of Tokyo Graduate School Of Medicine
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Oono Minoru
Department Of Cardiovascular Medicine The School Of Medicine The University Of Tokyo
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Oono Minoru
Department Of Cardiovascular Medicine The University Of Tokyo
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Hangaisi Misako
Department Of Cardiovascular Medicine The University Of Tokyo
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AIZAWA Tadanori
The Cardiovascular Instirute
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