Influence of Cerebrovascular Arteriosclerosis on Cerebral Oxygenation During Exercise
スポンサーリンク
概要
- 論文の詳細を見る
Background Although it is assumed that cerebral oxygenation during exercise is influenced by both cardiopul-monary function and cerebrovascular arteriosclerosis, the latter factor has not been fully clarified. In the present study the relationship between the degree of cerebrovascular arteriosclerosis and cerebral oxygenation during exercise was investigated. Methods and Results A total of 109 patients (69 patients with coronary artery disease, 40 patients with hypertensive heart disease) (61.1 ±9.1 years) performed a symptom-limited exercise test with respiratory gas measurements (CPX). From the respiratory gas analysis, peak O_2 uptake (VO_2), the slope of the increase in VO_2 to the increase in work rate (ΔVO_2/ΔWR), and the slope of the increase in ventilation to the increase in CO_2 output (VE/VCO_2 slope) were calculated. Oxyhemoglobin (O_2Hb) at the forehead was monitored using near-infrared spectroscopy. The brain ischemic score was counted based upon fluid-attenuated inversion recovery images of magnetic resonance imaging and expressed from 0 to 4. When compared with patients with a lower ischemic score (<2, n=67), those with a higher ischemic score (>2, n=42) had a lower increase in brain O_2Hb during exercise (-1.08±2.7 vs 0.77±4.1μmpl/L, p=0.011). Of brain ischemic score, left ventricular ejection fraction, peak VO_2, ΔVO_2/ΔWR, and the VE/VCO_2 slope, ΔVO_2/ΔWR was found to be the sole independent index determining cerebral O_2Hb during exercise. The CPX parameters were also significantly related to the degree of cerebrovascular arteriosclerosis. Conclusions Although cerebral oxygenation during exercise is mainly related to cardiopulmonary function, the degree of cerebrovascular arteriosclerosis partly influences cerebral oxygenation in patients with risk factors for atherosclerosis.
- 社団法人日本循環器学会の論文
- 2007-04-20
著者
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TAJIMA Akihiko
The Cardiovascular Institute, Graduate School of Health Sciences Tokyo Medical and Dental University
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ITOH Haruki
Department of Cardiology, Sakakibara Heart Institute
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AIZAWA Tadanori
The Cardiovascular Institute, Graduate School of Health Sciences Tokyo Medical and Dental University
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Itoh Haruki
Akita University School Of Medicine
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Itoh Hiroshi
Department Of Cardiovascular Medicine Tokyo Medical And Dental University
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IIMURA Hiroyuki
The Cardiovascular Institute
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Inoue Hiroshi
富山大学附属病院 神経内科
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Uejima Tokuhisa
The Cardiovascular Institute
-
Koike Akira
The Cardiovascular Institute
-
Uejima Tokuhisa
心臓血管研究所
-
Koike Akira
武蔵野赤十字病院
-
Aizawa Tadanori
The Cardiovascular Institute
-
Itoh Haruki
Department Of Cardiology Sakakibara Heart Institute
-
Goda Ayumi
The Cardiovascular Institute
-
Itoh Haruki
心臓血管研究所
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Takahashi Akihito
The Cardiovascular Institute
-
Iinuma Hiroyuki
鹿児島大学 大学院医歯学総合研究科循環器･呼吸器･代謝内科学
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Iinuma Hiroyuki
東京健生病院
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Itoh Haruki
Sakakibara Heart Institute Clinic
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Nagayama Osamu
The Cardiovascular Institute
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Itoh Haruki
Sakakibara Heart Institute
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Itoh Haruki
Cardiovascular Institute
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Tajima Akihiko
The Cardiovascular Institute
-
Hoshimoto Masayo
The Cardiovascular Institute
-
Yamaguchi Kaori
The Cardiovascular Institute
-
Gohda Ayumi
The Cardiovascular Institute
-
Itoh Haruki
Int. Medicine Yokosuka Mutual Aid Hospital.
-
Itoh Haruki
Heart Center The Second Department Of Internal Medicine St. Marianna University School Of Medicine H
-
Itoh Haruki
Department Of Internal Medicine Chiba Shakai-hoken Hospital
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Itoh Haruki
The 2nd Department Of Internal Medicine Tokyo Medical And Dental University
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Inagaki Hiroshi
Department Of Cardiovascular Medicine Tokyo Medical And Dental University
-
Uejima Tokuhisa
Department Of Cardiology The Cardiovascular Institute Hospital
-
Ito Hiroshi
Second Department Of Internal Medicine Tokyo Medical And Dental University
-
Ito Hiroshi
Akita University School Of Medicine
-
Hoshimoto‐iwamoto Masayo
Cardiovascular Inst. Tokyo Jpn
-
Gohda Ayumi
Department Of Cardiology The Cardiovascular Institute
-
Nagayama Osamu
Cardiovascular Institute School Of Health And Sports Science Juntendo University
-
NAGAYAMA Osamu
The Cardiovascular Instirute
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AIZAWA Tadanori
The Cardiovascular Instirute
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KOIKE Akira
The Cardiovascular Instirute
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