Effects of Supplemental O_2 Inhalation on Cerebral Oxygenation During Exercise in Patients With Left Ventricular Dysfunction

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Background It has been recently reported that cerebral oxyhemoglobin (O_2Hb) decreases during exercise in nearly 50% of patients with dilated cardiomyopathy. The present study evaluated whether the inhalation of supplemental O_2 diminishes the decrease in cerebral O_2Hb during exercise. Methods and Results Ten patients with a left ventricular ejection fraction <50% and a clearly observable decrease in cerebral O_2Hb during preliminary exercise testing underwent 2 additional symptom-limited incremental exercise tests: 1 while breathing room air (control) and the other while breathing 50% O_2. In the latter test, the switch from room air to 50% O_2 was performed, on average, at 43.0±14.2W. Cerebral O_2Hb was continuously monitored during exercise using near-infrared spectroscopy. In the control exercise test, cerebral O_2Hb gradually decreased as the work rate increased in all the subjects. When the subjects breathed 50% O_2, this decrease in cerebral O_2Hb was diminished. The change in cerebral O_2Hb from rest to peak exercise during the test under 50% O_2 was significantly higher than that during the control test (-0.23±1.89 vs -2.47±1.57μmol/L, p=0.002). Similarly, the change in the cerebral tissue oxygenation index was significantly higher in the test under 50% O_2 (0.45±4.46 vs -3.33±3.06%, p=0.023). Conclusions Impaired cerebral oxygenation during moderate to heavy intensity exercise in patients with left ventricular dysfunction can be offset by breathing supplemental O_2.
社団法人日本循環器学会の論文
2007-08-20

Effects of Supplemental O_2 Inhalation on Cerebral Oxygenation During Exercise in Patients With Left Ventricular Dysfunction

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