Oxygen Uptake Kinetics During and After Exercise are Useful Markers of Coronary Artery Disease in Patients With Exercise Electrocardiography Suggesting Myocardial Ischemia

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• Background: The aim of the current study was to determine if the slowed exercise oxygen uptake (VO2) kinetics, which is developed by myocardial ischemia, would be accompanied by delayed recovery VO2 kinetics in patients with coronary artery disease (CAD). Methods and Results: Thirty-seven patients with significant ST depression during treadmill exercise underwent cardiopulmonary exercise testing with cycle ergometer. Measurements performed are the ratios of change in increase in oxygen (O2) uptake relative to increase in work rate (ΔVO2/ΔWR) across anaerobic threshold (AT) and 1 mm ST depression point (ST-dep), the time constants of VO2 during recovery (T1/2 VO2), stress radio-isotope scintigraphy and coronary angiography. Patients were divided into CAD positive (CAD+) and CAD negative (CAD-) groups, based on coronary angiography. In CAD+, ΔVO2/ΔWR decreased above AT and ST-dep, in contrast to CAD- patients. The T1/2 VO2 in CAD+ (103.1 ±13.0 s) was greater than that of CAD- (76.5 ±8.7 s) and showed negative correlations to the ratios of ΔVO2/ΔWR across AT and ST-dep. These parameters improved in the patients who underwent coronary bypass surgery. Conclusions: Exercise and recovery VO2 kinetics were slowed when myocardial ischemia was provoked by exercise. Measurement of exercise and recovery VO2 kinetics improve the accuracy of the exercise electrocardiogram diagnosis of CAD.

• 2009-09-20

著者

• TAJIMA Akihiko

  The Cardiovascular Institute, Graduate School of Health Sciences Tokyo Medical and Dental University

• ITOH Haruki

  Department of Cardiology, Sakakibara Heart Institute

• OSADA Naohiko

  The Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medic

• OMIYA Kazuto

  The Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medic

• MAEDA Tomoko

  Department of Cardiology, Sakakibara Heart Institute

• OHKOSHI Nobuyuki

  The Cardiovascular Institute, Graduate School of Health Sciences Tokyo Medical and Dental University

• KAWARA Tokuhiro

  Biofunctional Informatics, Graduate School of Health Sciences Tokyo Medical and Dental University

• AIZAWA Tadanori

  The Cardiovascular Institute, Graduate School of Health Sciences Tokyo Medical and Dental University

• WASSERMAN Karlman

  Respiratory and Critical Care Physiology and Medicine, Harbor-UCLA Medical Center

• Itoh Haruki

  Akita University School Of Medicine

• Itoh Hiroshi

  Department Of Cardiovascular Medicine Tokyo Medical And Dental University

• IIMURA Hiroyuki

  The Cardiovascular Institute

• Inoue Hiroshi

  富山大学附属病院 神経内科

• Inoue H

  Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Aizawa Tadanori

  The Cardiovascular Institute

• Aizawa Tadanori

  東京慈恵会医科大学 医学部循環器内科学

• Aizawa Tadanori

  心臓血管研究所

• Itoh Haruki

  Department Of Cardiology Sakakibara Heart Institute

• Itoh Haruki

  心臓血管研究所

• Takahashi Akihito

  The Cardiovascular Institute

• Osada Naohiko

  Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine

• Osada Naohiko

  聖マリアンナ医科大学 循環器内科

• Osada Naohiko

  St. Marianna University School Of Medicine Division Of Internal Medicine

• Iinuma Hiroyuki

  鹿児島大学 大学院医歯学総合研究科循環器･呼吸器･代謝内科学

• Iinuma Hiroyuki

  東京健生病院

• Kawara Tokuhiro

  Biofunctional Informatics Graduate School Of Health Sciences Tokyo Medical And Dental University

• Ohba Kageyuki

  横浜市立みなと赤十字病院 循環器科

• Aizawa T

  The Cardiovascular Institute

• Omiya Kazuto

  聖マリアンナ医科大学 循環器内科

• Omiya Kazuto

  Japanese Cardiac Rehabilitation Research Group (ministry Of Health Labor And Welfare 15a-2)

• Itoh Haruki

  Cardiovascular Institute

• Wasserman Karlman

  Respiratory And Critical Care Physiology And Medicine Harbor-ucla Medical Center

• Inoue H

  Dept. Biotechnology Faculty Of Engineering Sciences

• Inoue Hiroki

  Department Of Chemistry Faculty Of Science Kyushu University

• Tajima Akihiko

  The Cardiovascular Institute

• Aizawa Tadanori

  The Cardiovascular Institute Nippon Medical School

• Kawara Tokuhiro

  Biofunctional Informatics Graduate School Of Allied Health Sciences Tokyo Medical And Dental Univers

• Maeda Tomoko

  Department Of Cardiology Sakakibara Heart Institute

• Itoh Haruki

  Int. Medicine Yokosuka Mutual Aid Hospital.

• Iinuma Hiroyuki

  Second Department Of Internal Medicine University Of Toyama

• Aizawa Toru

  Department Of Cardiovascular Medicine University Of Tokyo Graduate School Of Medicine

• Maeda Tomoko

  Department Of Anatomy And Anthropology Tohoku University School Of Medicine

• Itoh Haruki

  Heart Center The Second Department Of Internal Medicine St. Marianna University School Of Medicine H

• Itoh Haruki

  Department Of Internal Medicine Chiba Shakai-hoken Hospital

• Oikawa Keiko

  Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine

• Itoh Haruki

  The 2nd Department Of Internal Medicine Tokyo Medical And Dental University

• Oomiya Kazuto

  Division Of Cardiology St. Marianna University School Of Medicine

• Inagaki Hiroshi

  Department Of Cardiovascular Medicine Tokyo Medical And Dental University

• Aizawa Tadanori

  Toho University School Of Medicine Cardiovascular Institute

• Ito Hiroshi

  Second Department Of Internal Medicine Tokyo Medical And Dental University

• Ito Hiroshi

  Akita University School Of Medicine

• Ohkoshi Nobuyuki

  The Cardiovascular Institute Graduate School Of Health Sciences Tokyo Medical And Dental University

• Oomiya Kazuto

  The 2nd Departmen Of Internal Medicine St. Marianna University School Of Medicine

• Ito Hiroshi

  Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine

• Itoh Haruki

  Department Of 2nd Internal Medicine St.marianna University School Of Medicine

• Aizawa Tadanori

  Cardiovascular Institute School Of Health And Sports Science Juntendo University

• Aizawa Tadanori

  Department Of Internal Medicine Cardiovascular Institute Hospital

• Osada Naohiko

  Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine

• AIZAWA Tadanori

  The Cardiovascular Instirute

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