Clinical Significance of Cerebral Oxygenation During Exercise in Patients With Coronary Artery Disease

概要

論文の詳細を見る
Background Recent investigations have demonstrated that cerebral oxyhemoglobin (O_2Hb) decreases during exercise in patients with left ventricular dysfunction, reflecting a cerebral hypoxia. We sought to establish a prognostic value of decreased cerebral O_2Hb during exercise in cardiac patients, and to compare it with those of indexes obtained from cardiopulmonary exercise testing (CPX). Methods and Results A total of 344 consecutive patients with coronary artery disease were enrolled in the study. All the patients performed CPX, during which cerebral O_2Hb was continuously monitored using nearinfrared spectroscopy. There were 13 cardiac deaths and 78 cardiovascular events during the prospective follow-up period of 1,231±538 days. The change of O_2Hb measured at the forehead from rest to peak exercise (ΔO_2Hb) was significantly lower in non-survivors than in survivors (-1.5±3.3 vs 1.7±3.2μmol/L, p=0.0004). By multivariate Cox proportional hazards analysis, ΔO_2Hb and left ventricular ejection fraction (LVEF) were found to be independent prognostic markers for cardiac deaths. The ΔO_2Hb, LVEF and peak oxygen uptake were found to be significant prognostic markers for cardiovascular events, mainly for heart failure worsening and sudden cardiac death. Conclusion The present findings suggest that a decrease in cerebral O_2Hb during exercise predicts future cardiovascular events in patients with coronary artery disease.
社団法人日本循環器学会の論文
2008-10-20

Clinical Significance of Cerebral Oxygenation During Exercise in Patients With Coronary Artery Disease

スポンサーリンク

概要

著者

関連論文

スポンサーリンク