Serial Alterations and Prognostic Implications of Myocardial Perfusion and Fatty Acid Metabolism in Patients With Acute Myocardial Infarction

スポンサーリンク

概要

• 論文の詳細を見る

• Background Impaired fatty acid metabolism the myocardial infarction (MI)-related area has prognostic value, but can alter over time. The aim of this study was to correlate alterations in myocardial fatty acid uptake and perfusion assessed by serial imaging with future outcomes in post-MI patients. Methods and Results Following 2 imaging procedures using 15-4-iodophenyl-3-(R,S)-methylpentadecanoic acid (BMIPP) and perfusion tracers at an 11-month interval, 97 patients with acute MI were followed up for 33 months with respect to the primary endpoints of death, non-fatal MI and heart failure. Regional tracer uptake was semi-quantified for both the MI-related and remote coronary territories. A large BMIPP defect relative to a perfusion defect appeared on Mi-related coronary territories. Thirteen patients with cardiac events had a greater prevalence of large BMIPP and perfusion defect scores for the Mi-related areas on the first scan, previous MI, diabetes mellitus, and worsening of perfusion tracer uptake in the Mi-related area than those without cardiac events. Multivariate analysis identified worsening perfusion in the MI-related area on the second scan, a large BMIPP defect in the same area on the first scan and previous MI as significant predictors with chi-square values of 3.48, 6.41 and 6.84, respectively. A combination of 3 predictors significantly (p<0.05) increased the global chi-square value to 15.45 compared with each chi-square value. Conclusions The size of the infarct-related risk area assessed by early cardiac BMIPP imaging and deterioration of perfusion tracer uptake in the compromised area for the first 12 months following acute MI are related to future cardiac events, indicating a rationale for identifying metabolically damaged but viable myocardium for further risk stratification of post-MI patients.

• 社団法人日本循環器学会の論文
• 2006-10-20

著者

• 小林 毅

  社会保険北海道健康保健管理センター

• 小林 毅

  社会保険北海道健康管理センター

• Tamaki Nagara

  Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University

• Fujita Masatoshi

  Kyoto University

• NAKATA Tomoaki

  Second Department of Internal Medicine, Sapporo Medical University School of Medicine

• HASHIMOTO Akiyoshi

  Second Department of Internal Medicine, Sapporo Medical University School of Medicine

• Nakata Tomoaki

  Second Department Of Internal Medicine (cardiology) Sapporo Medical University School Of Medicine

• Matsuki Takayuki

  Department of Cardiology, Shin-Nittetsu Muroran General Hospital

• 小林 毅

  岩見沢労災病院健診センター

• Matsuki Takayuki

  Department Of Cardiology Shin-nittetsu Muroran General Hospital

• KOBAYASHI Takeshi

  Division of Cardiovascular Medicine. Hokkaido university School of Medicine

• Furudate Masayori

  Hokkaido Cardiac Metabolism Imaging Study Group

• Hashimoto Akiyoshi

  Second Department Of Internal Medicine (cardiology) Sapporo Medical University School Of Medicine

• Kobayashi Takeshi

  Hokkaido Myocardial Metabolic Imaging Study Group

• Tamaki Nagara

  Department Of Cardiology Shiga Prefecture Medical Center For Adult

• Matsuki Takayuki

  Hokkaido Cardiac Metabolism Imaging Study Group

• Shogase Takashi

  Hokkaido Cardiac Metabolism Imaging Study Group

• Shohgase Takashi

  Hokkaido Cardiac Metabolism Imaging Study Group

• Sakamoto Takashi

  Department Of Cardiology Shin-nittetsu Muroran General Hospital

• Kobayashi Takeshi

  Hokkaido Cardiac Metabolism Imaging Study Group

• KOBAYASHI Takeshi

  Department of Cardiovascular Medicine, School of Medicine, Hokkaido University

• KOBAYASHI Takeshi

  Department of Cardiovascular Medicine, Hokkaido University, School of Medicine

• 小林 毅

  北海道大学医学部第一内科

関連論文

• LDLコレステロールが低値の急性心筋梗塞症例が有する脂質の特徴 : 一般住民健診受診者を対照群とした検討
• PE-364 Preliminary Report of a Multicenter Cohort Study of Myocardial Viability Assessment by Gated^Tc-Sestamibi SPECT at Rest(Nuclear cardiology-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• 塵肺病変部及び肺細小血管でのリポ蛋白 (a) (Lp(a)) 集積の意義
• 中高年者の心血管病変(動脈硬化)対策 : 特に低HDL-C血症を視野に入れた管理の必要性について
• "トライ13"プログラムの成果とその改善効果定着への追跡検討
• "トライ13"による生活習慣改善目標の達成度と検査値の改善に及ぼす要因について
• 生活習慣改善総合健康管理支援システム : "トライ13"の特徴とその意義について
• DETECTION OF EXERCISE-INDUCED SILENT ISCHEMIA AND THE SEQUENCE OF ISCHEMIC EVENTS IN CORONARY ARTERY DISEASE BY RADIONUCLIDE AMBULATORY VENTRICULAR FUNCTION MONITORING
• EFFECT OF REGIONAL MYOCARDIAL OXIDATIVE METABOLISM ON ABNORMAL LEFT VENTRICULAR WALL MOTION
• Positron Emission Tomography : Usefulness in assessing myocardial viability : ADVANCES IN IMAGING TECHNIQUES FOR DIAGNOSIS OF CARDIOVASCULAR DISEASES
• OE-084 Surgical Ventricular Reconstruction Improves Myocardial Oxidative Efficiency Assessed by ^ C-acetate PET and Echocardiography in Patients with Severe Heart Failure(OE15,Cardiac Function (Clinical) (M),Oral Presentation (English),The 73rd Annual
• Noninvasive Evaluation of Regional Myocardial Perfusion with Positron Emission Computed Tomography : PANEL DISCUSSION ON PROGRESS IN NONINVASIVE CARDIAC DIAGNOSIS
• イソシアネート取扱い作業者の特殊健康診断と過敏性肺臓炎の1症例 - 可溶性 CD23検索の意義 -
• Comparative study of ^Tl-scintigraphic image and myocardial pathologic findings in patients with dilated cardiomyopathy
• ^In Monoclonal Antimyosin Antibody Imaging : Imaging of Myocardial Infarction and Myocarditis : 53th Annual Scientific Session of the Japanese Circulation Society
• Recent advances in nuclear cardiology in the study of coronary artery disease
• Simplified quantification of regional cerebral blood flow with ^Tc-ECD SPECT and continuous arterial blood sampling
• Assessment of coronary vasodilator reserve by N-13 ammonia PET using the microsphere method and Patlak plot analysis
• 3 Diagnosis Procedure Combination in Private Hospitals(DPC and Clinical Practice of Cardiovascular Medicine, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PE-247 Detection of Ischemia in Patients with Acute Chest Pain by using Resting and Subsequent ATP Stress 99mTc-Tetrofosmin Myocardial SPECT(Nuclear Cardiology 9 (I) : PE42)(Poster Session (English))
• -1169-INDIUM-111 LABELED ANTIMYOSIN MONOCLONAL ANTIBODY FAB IMAGING : REPEATED STUDY AND ITS SAFETY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -0121-POSITRON EMISSION TOMOGRAPHY FOR EVALUATION OF MYOCARDIAL ISCHEMIA IN CORONARY ARTERY LESIONS AFTER KAWASAKI DISEASE
• MYOCARDIAL POSITRON COMPUTED TOMOGRAPHY WITH N-13 AMMONIA : Imaging Techniques : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Evaluation of coronary blood flow reserve by ^N-NH_3 positron emission computed tomography(PET) with dipyridamole in the treatment of hypertention with the ACE inhibitor(Cilazapril)
• Relation of Change in Wall Motion and Glucose Metabolism After Coronary Artery Bypass Grafting : Assessment with positron emission tomography : 54th Annual Scientific Session of the Japanese Circulation Society
• DETECTION OF ADRIAMYCIN CARDIOTOXICITY WITH INDIUM-111 LABELED ANTIMYOSIN MONOCLONAL ANTIBODY IMAGING
• INDIUM-111 LABELED ANTIMYOSIN MONOCLONAL ANTIBODY SCINTIGRAPHY IN MYOCARDITIS : EXPERIMENTAL AND CLINICAL STUDIES : Cardiomyopathy, Myocarditis : 53 Annual Scientific Meeting, Japanese Circulation Society
• PJ-098 Effects of Smoking Cessation on Coronary Endothelial Dysfunction in Young and Middle-aged Healthy Smokers(PJ017,Nuclear Cardiology (PET) (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Heterogeneous Reduction of Myocardial Oxidative Metabolism in Patients With Ischemic and Dilated Cardiomyopathy Using C-ll Acetate PET
• PJ-876 Myocardial β-adrenergic Receptor Density Assessed by ^C-CGP-PET Can Predict the Improvement of LVEF After Carvedilol in Patients with dilated cardiomyopathy(Heart failure, clinical(21)(M),Poster Session(Japanese),The 72nd Annual Scientific Meet
• Whole-body iodine-131 metaiodobenzylguanidine imaging for detection of bone metastases in patients with paraganglioma : comparison with bone scintigraphy
• Plasma Interleukin-6 and Tumor Necrosis Factor-α Can Predict Coronary Endothelial Dysfunction in Hypertensive Patients
• FRS-098 Relationship between Plasma Interleukin-6, Tumor Necrosis Factor-α, and Coronary Endothelial Dysfunction Assessed by , ^O-water PET in Hypertensive(Pathogenesis, Diagnosis and Complication of Hypertension, The 71st Annual Scientific Meeting of
• FRS-016 Decreased Myocardial Beta-adrenergic Receptor Density in Relation to Increased Sympathetic Tone in Patients with Nonischemic Cardiomyopathy : PET Study with ^C-CGP-12177(Advances in Nuclear Cardiology-1 (I) FRS4,Featured Research Session,The 7
• 3 Quantitative Assessment of Coronary Endothelial Function Using PET and Effects of Angiotensin Receptor Blockade Therapy in Patients with Hypertension(Advances in Cardiovascular Imaging,Symposium 7 (SY7) (I),The 70th Anniversary Annual Scientific Meeting
• 3 Reversible Coronary Endothelial Dysfunction by Smoking Cessation in Young Smokers : Assessment with O-15 Labeled Water and PET(Tobacco Free Symposium: The Present Condition of Tobacco Control in Japan, the Risk of Smoking to Cardio-and Cerebro-Vascular
• Quantitative Assessment of Regional Myocardial Blood Flow and Myocardial Flow Reserve Using Tc-99m-sestamibi Imaging(Nuclear Cardiology 4 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Assessment of Myocardial Beta-adrenergic Receptor Density in Patients with Congestive Heart Failure : PET Study with C-11-labeled-CGP-12177(Nuclear Cardiology 6 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Reversible Endothelial Dysfunction by Smoking Cessation in Healthy Young Smokers(Advances in Nuclear Cardiology (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-244 Impact of Smoking Cessation on Myocardial Blood Flow Dynamics Assessed with O-15 labeled Water and PET in Healthy Young Smokers(Nuclear Cardiology 6 (I) : OJ28)(Oral Presentation (Japanese))
• OE-021 Sympathetic Denervation and Reinnervation after Maze Procedure Assessed by I-123 MIBG SPECT(Nuclear Cardiology 1 (I) : OE3)(Oral Presentation (English))
• COMPARATIVE STUDY OF ^Tl-SCINTIGRAPHIC IMAGE AND ENDOMYOCARDIAL BIOPSY FINDINGS IN PATIENTS WITH DILATED CARDIOMYOPATHY
• Cardiovascular molecular Imaging(FRS10,Updates in Nuclear Cardiology (I),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-101 Impaired Coronary Vasomotor Response in Patients with Chronic Kidney Disease Using PET and N-13 Labeled Ammonia(PJ017,Nuclear Cardiology (PET) (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Restoration of Myocardial Flow Reserve Is Incomplete Early after Elective as Well as Direct PCI : Assessment by ^O-Water PET
• Gastrointestinal uptake of FDG after N-butylscopolamine or omeprazole treatment in the rat
• ^F-FDG PET is superior to ^Ga SPECT in the staging of non-Hodgkin's lymphoma
• Indium-111 Antimyosin Antibody Imaging and Thallium-201 Imaging : A Comparative Myocardial Scintigraphic Study Using Single-Photon Emission Computed Tomography in Patients With Myocarditis and Dilated Cardiomyopathy
• EFFECTS OF ALLOPURINOL ON CORONARY BLOOD FLOW IN EXPERIMENTAL MYOCARDIAL ISCHEMIA : (Part II)
• CHANGES IN MYOCARDIAL CONTRACTILITY OF BOTH VENTRICULES INDUCED BY AN ACUTE RIGHT VENTRICULAR PRESSURE OVERLOAD : PROCEEDINGS OF THE 37TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Assessment of cervical lymph node metastases using FDG-PET in patients with head and neck cancer
• Normal BMIPP imaging is an excellent prognostic sign in patients with angina pectoris : Comparison with stress myocardial perfusion imaging
• PE-552 Diagnostic Accuracy of New Generator-produced 82Rubidium Myocardial Perfusion Positron Emission Tomography in the Detection of Coronary Artery Disease(Nuclear cardiology(06)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japan
• Clinical impact of whole body FDG-PET for recurrent biliary cancer : a multicenter study
• IDENTIFICATION OF PATIENTS WITH CORONARY ARTERY DISEASE USING A SCORING SYSTEM OF CORONARY RISK FACTORS, ELECTROCARDIOGRAPHY AND MYOCARDIAL PERFUSION IMAGING
• PROGNOSTIC VALUE OF I-123-MIBG IMAGING IN PATIENTS WITH LEFT VENTRICULAR DYSFUNCTION : A MULTICENTER TRIAL IN HOKKAIDO
• Impairment of coronary vasomotor response to cold pressor stress in healthy young smokers
• ^O-Water Perfusable Tissue Fraction in Patients with Dilated Cardiomyopathy
• Impairment of myocardial flow reserve and endothelial function even in apparently normal coronary regions after Kawasaki disease using 15O-water PET
• Quantitative Assessment of Myocardial Flow Reserve with Tc-99m-MIBI : Comparison with the Results of Measured by O-15-Water PET
• Time-course of functional recovery after CABG : Serial assessment by quantitative gated SPECT
• Functional recovery with dobutamine stress echocardiography is dependent on maintenance of oxidative metabolic response : Comparison with carbon-11 acetate PET
• Reduction of coronary flow reserve in areas with and without ischemia on SPECT : comparison with ^Tc tetrofosmin SPECT and H_2 ^ PET
• FRS-114 Heterogeneous Myocardial Oxidative Metabolism in Patients with Left Bundle Branch Block and Right Ventricular Pacing(Nuclear Cardiology (I) : FRS14)(Featured Research Session (English))
• Myocardial Blood Flow Reserve as Indices of Coronary Artery Stenosis and Risk Factors
• PJ-290 Increased Coronary Vascular Resistance during Hyperemia was Associated with Reduced Myocardial Blood Volume in Patients with Hypertrophic Cardiomyopathy(Echo/Doppler(13)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese
• OJ-169 Reduced Myocardial Blood Volume is Associated with Impairment of Regional Myocardial Flow Reserve in Hypertrophic Cardiomyopathy(Echo/Doppler-4 (I) OJ29,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Cir
• Diagnostic Value of ^I-Betamethyl-p-Iodophenyl-Pentadecanoic Acid (BMIPP) Single Photon Emission Computed Tomography (SPECT) in Patients With Chest Pain : Comparison With Rest-Stress ^Tc-Tetrofosmin SPECT and Coronary Angiography
• EFFECTS OF OUABAIN, FUROSEMIDE AND AMINOPHYLLINE ON THE PULMONARY CIRCULATION OF THE EXCISED DOG'S LUNG LOBE : IInd Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• STUDIES ON EXPERIMENTAL PULMONARY EMBOLISM
• -295-CENTRALLY MEDIATED CARDIOVASCULAR EFFECTS OF DIGOXIN : Cardiotonics : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -84- PROGNOSTIC IMPLICATION OF RIGHT AND LEFT VENTRICULAR DYSFUNCTIONS AND EXERCISE TESTING IN THE POST-MYOCARDIAL INFARCTION PATIENT : Congestive Heart Failure : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE C
• -1053-EFFECTS OF ENDOTHELIUM-DERIVED RELAXING FACTOR ON BLOOD PRESSURE AND CENTRAL AUTONOMIC NEVER CONTROL : AN ASSESSMENT USING L-N^G-MONO-METHYLARGININE : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -0566-THE IN VIVO MEASUREMENT OF THE MYOCARDIAL INTERSTITIAL POTASSIUM AND LACTATE CONCENTRATIONS IN THE BEATING CANINE HEART USING AN IMPROVED MICRODIALSIS TECHNIQUE
• DIPYRIDAMOLE POTENTIATES EDRF-MEDIATED INHIBITION OF PLATELET AGGREGATION : THE ROLE OF DIPYRIDAMOLE IN VIVO AS A CYCLIC GMP PHOSPHODIESTERASE INHIBITOR : Myocardial Metabolism, Biochemistry : 53 Annual Scientific Meeting, Japanese Circulation Society
• -264- A NEW THROMBOLYTIC THERAPY USING AUTOLOGOUS PLASMIN RICH PLASMA : Ischemic Heart Diseases : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -P97- USEFULNESS OF RIGHT ATRIAL FUNCTION ANALYSIS IN THE PATIENTS WITH HEART DISEASE : RI : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• THE POTENTIATED THROMBOLYSIS UNDER SELECTIVE INFUSION OF AUTO PLASMIN RICH PLASMA (APRP) : PTCA, Thrombosis : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• THE POTENTIATED THROMBOLYSIS USING AUTOPLASMIN RICH PLASMA (APRP) UNDER SELECTIVELY BLOOD FLOW OBSTRUCTION TRANSIENTLY PRODUCED BY BALLOON-TIP CATHETER : Ischemic Heart Disease (III) : FREE COMMUNICATIONS (III) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC
• RIGHT AND LEFT VENTRICULAR FUNCTION DURING EXERCISE IN PATIENTS WITH CORONARY ARTERY DISEASE : Radio Isotope : 46th Annual Scientific Meeting, Japanese Circulation Society
• POTENTIATION OF TOXICITY AND POSITIVE INOTROPIC EFFECT OF OUABAIN BY FUROSEMIDE IN GUINEA PIG HEART
• Evaluation of the Left Ventricular Performance in Patients with Ischemic Heart Disease Using Radionuclide Angiocardiography : The Present Status of Cordiovascular Nuclear Medicine
• SENSITIVITY OF THALLIUM-201 IMAGING FOLLOWING PHARMACOLOGIC VASODILATION BY DIPYRIDAMOLE IN DETECTING CORONARY ARTERY STENOSIS : Isotope Imaging : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• The Non-invasive Evaluation of Regional Myocardial Ischemia Studied by a "Stress-injected" Thallium-201 Myocardial Imaging and a Radionuclide Left Ventriculography : Symposium on Myocardial Ischemia
• CHANGES OF HUMORAL AGENTS IN PHYSICAL EXERCISE BY BICYCLE ERGOMETER : IInd Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• EFFECTS OF FUROSEMIDE AND SOLUDACTONE ON OUABAIN TOXICITY IN GUINEA PIGS : IInd Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -P439- Assessment of myocardial perfusion and fatty acid metabolism in old myocardial infarction : occurence of mismatched uptake of BMIPP and thallium(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• Serial Alterations and Prognostic Implications of Myocardial Perfusion and Fatty Acid Metabolism in Patients With Acute Myocardial Infarction
• Perfusion-BMIPP Mismatched Area Is Related to Future Cardiac Events in Patients Survived Following Acute Myocardial Infarction
• Prognostic Value of Myocardial Fatty Acid Imaging in Patients with Coronary Heart Disease
• THALLIUM-201 (Tl-201). TECHNETIUM-99m PYROPHOSPHATE (Tc-PYP) MYOCARDIAL IMAGING FOR ISCHEMIC HEART DISEASE : IVth Auditorium
• Right Ventricular Massive Calcification Associated with Pulmonic Stenosis and Incompetence
• -204-THE PRESSOR RESPONSE TO VASOACTIVE AGENTS STIMULATES THE RELEASE OF THROMBOXANE A2 IN HYPERCHOLESTROL-EMIC RABBITS : Coronary Circulation : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• THE EFFECT OF VASOACTIVE SUBSTANCES TO THE PRODUCTION OF THROMBOXANE A2 AND : PROCEEDINGS IN HYPERCHOLESTEROLEMIC RABBITS : Coronary Circulation (II) : FREE COMMUNICATIONS (IV) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATIO
• PHOSPHOLIPASE ACTIVITY IN KIDNEY OF SPONTANEOULSY HYPERTENSIVE RATS : Hypertension (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
• EFFECT OF GUANETHIDINE, CLONIDINE AND GUANFACINE ON URINARY CATECHOLAMINE EXCRETION IN COLD-STRESSED SPONTANEOUSLY HYPERTENSIVE RATS
• Conditions for "Coronary Steal" Caused by Coronary Vasodilator in Man
• A Case of Variant Angina with Normal Coronary Arteriogram Who Developed Acute Myocardial Infarction and Cerebral Embolism
• Congenital Aortic Regurgitation Observed in a Thalidomide-Deformed Child
• LDLコレステロールが低値の急性心筋梗塞症例が有する脂質の特徴：一般住民健診受診者を対照群とした検討

もっと見る 閉じる

スポンサーリンク