Potential of Selected Strains of Lactic Acid Bacteria to Induce a Th1 Immune Profile
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概要
- 論文の詳細を見る
Lactic acid bacteria (LAB) might switch the Th2 biased immune response in allergic patients towards a balanced Th1/Th2 immune profile, leading to amelioration of allergy. To select strains of LAB that could be of potential application for foods in controlling allergy, 35 bacterial strains were screened in vitro using murine splenocytes and peritoneal exudate cells (PECs). Streptococcus thermophilus AHU1838 (FERM AP-21009), and Lactobacillus paracasei subsp. casei AHU1839 (FERM AP-21010) enhanced the secretion of Th1 cytokines such as interferon-γ (IFN-γ) and interleukin-12 (IL-12). The two strains of LAB also up-regulated the expression of CD40, and CD86 in dendritic cells (DCs), and activated cytotoxic T lymphocytes (CTL). These two strains could therefore be used in producing fermented food products that can enhance the Th1 immune profile which is important in ameliorating allergy.
- 社団法人 日本農芸化学会の論文
著者
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NISHIMURA Takashi
Division of Immunoregulation, Institute for Genetic Medicine, Hokkaido University
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Sone Teruo
Laboratory of Applied Microbiology, Graduate School of Agriculture, Hokkaido University
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Tanaka Michiko
Laboratory of Applied Microbiology, Graduate School of Agriculture, Hokkaido University
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Asano Kozo
Laboratory of Applied Microbiology, Graduate School of Agriculture, Hokkaido University
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Tanaka Michiko
Laboratory Of Applied Microbiology Graduate School Of Agriculture Hokkaido University
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Takebayashi M
Laboratory Of Applied Microbiology Graduate School Of Agriculture Hokkaido University
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Ongol Martin
Laboratory of Applied Microbiology, Graduate School of Agriculture, Hokkaido University
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Iguchi Takeshi
Fujiya Co., Ltd., Fundamental Research Laboratory
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IKEDA Hiroaki
Faculty of Medicine, Mie University
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