Protein Deficiency Impairs DNA Vaccine-Induced Antigen-Specific T Cell but Not B Cell Response in C57BL/6 Mice
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概要
- 論文の詳細を見る
DNA vaccination is a simple method to induce antigen (Ag)-specific immunoresponse and has many potential advantages over other vaccines. Although people who need to receive vaccines often suffer undernutrition, there has been no study on a how nutritional status affects the immunoresponse induced by DNA vaccination. The aim of this study was to determine the relationship between protein deficiency and DNA vaccineinduced immunoresponses. C57BL/6 mice were fed a 5% or 20% casein diet for 30 d. The mice were immunized with an ovalubumin (OVA)-expression plasmid by the gene gunbased method three times at 10-d intervals. Body weight and serum albumin concentration in protein-deficient mice were significantly lower than those in mice fed the 20% casein diet (p<0.01, p<0.05). The percentage of OVA-specific CD8^+ T cells was significantly decreased in the 5% casein group compared to that in the 20% casein group (p<0.05). Furthermore, CD4^+ T cells from mice fed the low-protein diet showed lower interleukin (IL)-2 production than did those from the 20% group. In contrast to the T-cell function, protein deficiency did not affect OVA-specific Ab responses (p>0.05). These results suggest that protein deficiency impairs the induction of Ag-specific T-cell but not B-cell response in DNA-immunized mice. Our observation indicates that, in addition to development of an effective of DNA vaccine, the management of nutritional state is important for the prevention of infectious disease by DNA vaccination.
- 日本ビタミン学会の論文
著者
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YAMAMOTO Shigeru
Department of Nutrition and Food Science, Ochanomizu University
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KOGISO Mari
Department of Chemistry and Bioscience, Faculty of Science, Kagoshima University
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Kogiso Mari
Department Of International Nutrition Institute Of Health Biosciences The University Of Tokushima Gr
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Kogiso Mari
Department Of Chemistry And Bioscience Faculty Of Science Kagoshima University
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Yamamoto Shigeru
Dep. Of Nutrition And Food Sci. Ochanomizu Univ.
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Yamamoto S
Department Of International Public Health Nutrition Institute Of Health Biosciences The University O
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SAKAI Tohru
Department of International Public Health Nutrition
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MITSUYA Kaori
Department of International Nutrition, Institution of Health Bioscience, The University of Tokushima
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ONO Kaori
Department of International Nutrition, Institution of Health Bioscience, The University of Tokushima
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KOMATSU Tatsushi
Department of Clinical Nutrition, Osaka Prefecture University
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Sakai Tohru
Dep. Of Public Health And Applied Nutrition Inst. For Health Biosciences The Univ. Of Tokushima
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Sakai Tohru
Department Of Clinical Nutrition Osaka Prefecture University
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Sakai Tohru
Department Of International Nutrition Institute Of Health Biosciences The University Of Tokushima Gr
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Yamamoto Shigeru
Department Of International Nutrition Institute Of Health Biosciences The University Of Tokushima Gr
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Ono Kaori
Department Of International Nutrition Institution Of Health Bioscience The University Of Tokushima G
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Mitsuya Kaori
Department Of International Nutrition Institute Of Health Biosciences The University Of Tokushima Gr
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Komatsu Tatsushi
Department Of Clinical Nutrition Osaka Prefecture University
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Komatsu Tatsushi
Department Of Clinical Nutrition Faculty Of Comprehensive Rehabilitation Osaka Prefecture University
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Yamamoto Shigeru
International Nutrition Ochanomizu University Graduate School Of Humanities And Sciences
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Yamamoto Shigeru
Department Of Biology Faculty Of Science Kyushu University
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Sakai Tohru
Department Of Public Health And Applied Nutrition Institute Of Health Biosciences The University Of Tokushima Graduate School
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SAKAI TOHRU
Department of Chemical Engineering, Toyama University
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