The Soy Isoflavone Equol Enhances Antigen-Specific IgE Production in Ovalbumin-Immunized BALB/c Mice
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概要
- 論文の詳細を見る
Although an immunomodulatory role of the soy isoflavone genistein has been demonstrated, the effects of other soy isoflavones on induction of antigen (Ag)-specific immune responses are not known. In this study, we therefore investigated the effects of daidzein and equol on ovalbumin (OVA)-specific T cell and B cell responses in BALB/c mice. Mice that had been treated with 20 mg/kg equol showed a significantly higher level of OVA-specific IgE than control mice. Levels of interferon (IFN)-γ and interleukin (IL)-4 production were not different between the control and equol groups. However, IL-13 production level in mice administered 20 mg/kg equol was significantly higher than that in control mice. Strong induction of OVA-specific IgE production by equol was also observed in ovariectomized BALB/c mice, suggesting that the immunomodulatory effect of equol is not affected by endogenous estrogen.
- 2010-02-01
著者
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SONE Saburo
Department of Internal Medicine and Molecular Therapeutics, The University of Tokushima Graduate Sch
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SAKAI Tohru
Department of International Public Health Nutrition
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Sakai Tohru
Dep. Of Public Health And Applied Nutrition Inst. For Health Biosciences The Univ. Of Tokushima
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Sakai Tohru
Department Of Clinical Nutrition Osaka Prefecture University
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Sakai Tohru
Department Of Public Health And Applied Nutrition Institute For Health Biosciences The University Of
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Hosaka Toshio
Department Of Public Health And Applied Nutrition Institute For Health Biosciences The University Of
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NISHIOKA Yasuhiko
Department of Internal Medicine and Molecular Therapeutics, University of Tokushima School of Medici
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Sakai Tohru
Department Of International Nutrition Institute Of Health Biosciences The University Of Tokushima Gr
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Sone Saburo
Department Of Respiratory Medicine And Rheumatology Institute For Health Biosciences The University
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Sone Saburo
Dep. Of Respiratory Medicine And Rheumatology Inst. For Health Biosciences The Univ. Of Tokushima
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FUROKU Sakina
Department of Public Health and Applied Nutrition, Institute for Health Biosciences, The University
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NAKAMOTO Mariko
Department of Public Health and Applied Nutrition, Institute for Health Biosciences, The University
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SHUTO Emi
Department of Public Health and Applied Nutrition, Institute for Health Biosciences, The University
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Shuto Emi
Dep. Of Public Health And Applied Nutrition Inst. Of Health Biosciences The Univ. Of Tokushima Gradu
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Nishioka Yasuhiko
Department Of Internal Medicine And Molecular Therapeutics Institute Of Health Biosciences The Unive
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Sone Saburo
Department Of Internal Medicine And Molecular Therapeutics Institute Of Health Biosciences The Unive
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Nakamoto Mariko
Department Of Public Health And Applied Nutrition Institute Of Health Biosciences The University Of
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Furoku Sakina
Department Of Public Health And Applied Nutrition Institute Of Health Biosciences The University Of
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Shuto Emi
Department Of Public Health And Applied Nutrition Institute Of Health Biosciences The University Of
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Nishioka Yasuhiko
Department Of Respiratory Medicine And Rheumatology Institute For Health Biosciences The University
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Sakai Tohru
Department Of Public Health And Applied Nutrition Institute Of Health Biosciences The University Of Tokushima Graduate School
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Hosaka Toshio
Department Of Endocrinology And Diabetes School Of Medicine Saitama Medical University
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SONE Saburo
Department of Internal Medicine and Molecular Tharapeutics, University of Tokushima School of Medicine
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SAKAI TOHRU
Department of Chemical Engineering, Toyama University
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Nakamoto Mariko
Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
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