The Soy Isoflavone Equol Enhances Antigen-Specific IgE Production in Ovalbumin-Immunized BALB/c Mice
スポンサーリンク
概要
- 論文の詳細を見る
Although an immunomodulatory role of the soy isoflavone genistein has been demonstrated, the effects of other soy isoflavones on induction of antigen (Ag)-specific immune responses are not known. In this study, we therefore investigated the effects of daidzein and equol on ovalbumin (OVA)-specific T cell and B cell responses in BALB/c mice. Mice that had been treated with 20 mg/kg equol showed a significantly higher level of OVA-specific IgE than control mice. Levels of interferon (IFN)-γ and interleukin (IL)-4 production were not different between the control and equol groups. However, IL-13 production level in mice administered 20 mg/kg equol was significantly higher than that in control mice. Strong induction of OVA-specific IgE production by equol was also observed in ovariectomized BALB/c mice, suggesting that the immunomodulatory effect of equol is not affected by endogenous estrogen.
- 2010-02-01
著者
-
SONE Saburo
Department of Internal Medicine and Molecular Therapeutics, The University of Tokushima Graduate Sch
-
SAKAI Tohru
Department of International Public Health Nutrition
-
Sakai Tohru
Dep. Of Public Health And Applied Nutrition Inst. For Health Biosciences The Univ. Of Tokushima
-
Sakai Tohru
Department Of Clinical Nutrition Osaka Prefecture University
-
Sakai Tohru
Department Of Public Health And Applied Nutrition Institute For Health Biosciences The University Of
-
Hosaka Toshio
Department Of Public Health And Applied Nutrition Institute For Health Biosciences The University Of
-
NISHIOKA Yasuhiko
Department of Internal Medicine and Molecular Therapeutics, University of Tokushima School of Medici
-
Sakai Tohru
Department Of International Nutrition Institute Of Health Biosciences The University Of Tokushima Gr
-
Sone Saburo
Department Of Respiratory Medicine And Rheumatology Institute For Health Biosciences The University
-
Sone Saburo
Dep. Of Respiratory Medicine And Rheumatology Inst. For Health Biosciences The Univ. Of Tokushima
-
FUROKU Sakina
Department of Public Health and Applied Nutrition, Institute for Health Biosciences, The University
-
NAKAMOTO Mariko
Department of Public Health and Applied Nutrition, Institute for Health Biosciences, The University
-
SHUTO Emi
Department of Public Health and Applied Nutrition, Institute for Health Biosciences, The University
-
Shuto Emi
Dep. Of Public Health And Applied Nutrition Inst. Of Health Biosciences The Univ. Of Tokushima Gradu
-
Nishioka Yasuhiko
Department Of Internal Medicine And Molecular Therapeutics Institute Of Health Biosciences The Unive
-
Sone Saburo
Department Of Internal Medicine And Molecular Therapeutics Institute Of Health Biosciences The Unive
-
Nakamoto Mariko
Department Of Public Health And Applied Nutrition Institute Of Health Biosciences The University Of
-
Furoku Sakina
Department Of Public Health And Applied Nutrition Institute Of Health Biosciences The University Of
-
Shuto Emi
Department Of Public Health And Applied Nutrition Institute Of Health Biosciences The University Of
-
Nishioka Yasuhiko
Department Of Respiratory Medicine And Rheumatology Institute For Health Biosciences The University
-
Sakai Tohru
Department Of Public Health And Applied Nutrition Institute Of Health Biosciences The University Of Tokushima Graduate School
-
Hosaka Toshio
Department Of Endocrinology And Diabetes School Of Medicine Saitama Medical University
-
SONE Saburo
Department of Internal Medicine and Molecular Tharapeutics, University of Tokushima School of Medicine
-
SAKAI TOHRU
Department of Chemical Engineering, Toyama University
-
Nakamoto Mariko
Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
関連論文
- The Novel Src Kinase Inhibitor M475271 Inhibits VEGF-Induced Vascular Endothelial-Cadherin and β-Catenin Phosphorylation but Increases Their Association
- A Novel Src Kinase Inhibitor, M475271, Inhibits VEGF-Induced Human Umbilical Vein Endothelial Cell Proliferation and Migration
- The Soy Isoflavone Equol Enhances Antigen-Specific IgE Production in Ovalbumin-Immunized BALB/c Mice
- Increased Nerve Growth Factor by Zinc Supplementation with Concurrent Vitamin A Deficiency Does Not Improve Memory Performance in Mice
- Protein Deficiency Impairs DNA Vaccine-Induced Antigen-Specific T Cell but Not B Cell Response in C57BL/6 Mice
- Genistein Enhances Antigen-Specific Cytokine Production in Female DO11.10 Transgenic Mice
- Genistein Suppresses Development of Spontaneous Atopic-Like Dermatitis in NC/Nga Mice
- Deletion Polymorphisms in the Promoter Region of Fcγ Receptor IIB Is Not Associated with Antigen-Specific IgG2a and IgG2b Antibody Responses in NC/Nga Mice
- Defect in Toll-like Receptor-Mediated Activation in NC/Nga Mouse Macrophages
- Multfunctional interleukin-1β promotes metastasis of human lung cancer cells in SCID mice via enhanced expression of adhesion-, invasion- and angiogenesis-related molecules
- Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2
- IgE Responses in Mice Fed Moderate Protein Deficient and High Protein Diets
- Treatment with cathepsin L inhibitor potentiates t_h2-type immune response in Leishmania major-infected BALB/c mice
- Novel orthotopic implantation model of human malignant pleural mesothelioma (EHMES-10 cells) highly expressing vascular endothelial growth factor and its receptor
- Effect of Vietnamese Common Diet on Postprandial Blood Glucose Level in Adult Females
- Current status and perspective of angiogenesis and antivascular therapeutic strategy : non-small cell lung cancer
- MOLECULAR MECHANISMS OF ANGIOGENESIS IN NON-SMALL CELL LUNG CANCER, AND THERAPEUTICS TARGETING RELATED MOLECULES
- Molecular mechanisms of angiogenesis in non-small cell lung cancer, and therapeutics targeting related molecules
- A report of two bronchioloalveolar carcinoma cases which were rapidly improved by treatment with the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 ("Iressa"^1)
- Angiogenesis in the Progression of Lung Cancer
- CD4^+ T cells are required for HSP65 expression in host macrophages and for protection of mice infected with Plasmodium yoelii
- CD4^+ Vα 14 NKT cells play a crucial role in an early stage of protective immunity against infection with Leishmania major
- DNA immunization with Plasmodium falciparum serine repeat antigen: regulation of humoral immune response by coinculation of cytokine expression plasmid
- Experission of heat shock protein in host macrophages correlates with a protective potential against infection with Leishmania major in mice
- Development of Functional Rat-Derived T Cells in SCID Mice Engrafted with the Fetal Thymus of LEC Rats Which Are Defective in CD4^+ T Cells
- Modulation of Oral Tolerance to Ovalbumin by Dietary Protein in Mice
- Tumor suppressor genes in human lung cancer
- Soluble Fas in malignant pleural effusion and its expression in lung cancer cells
- Dietary Trans Fatty Acids Suppress the Development of Spontaneous Atopic-Like Dermatitis in NC/Nga Mice
- Postprocessing technique with MDCT data improves the accuracy of the detection of lung nodules
- Suppression of Oral Tolerance by Lactococcus lactis in Mice
- Transforming growth factor β stimulates rheumatoid synovial fibroblasts via the type II receptor
- Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice
- IgE Responses in Mice Fed Moderate Protein Deficient and High Protein Diets
- 6. Angiogenesis in the Progression of Lung Cancer
- Multifunctional interieukin-1 beta promotes metastasis of human lung cancer cells in SCID mice via enhanced expression of adhesion-, invasion- and angiogenesis-related molecules
- Molecular mechanisms of angiogenesis in non-small cell lung cancer, and therapeutics targeting related molecules
- Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors : A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study
- The Novel Src Kinase Inhibitor M475271 Inhibits VEGF-Induced Vascular Endothelial-Cadherin and β-Catenin Phosphorylation but Increases Their Association
- Genetically engineered humanized anti-ganglioside GM2 antibody against multiple organ metastasis produced by GM2-expressing small-cell lung cancer cells
- Inverse Correlation Between Coffee Consumption and Prevalence of Metabolic Syndrome: Baseline Survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima, Japan
- Extracts of Common Buckwheat Bran Prevent Sucrose Digestion
- Hypoglycemic effects of colestimide on type 2 diabetic patients with obesity
- Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet
- Inverse Correlation Between Coffee Consumption and Prevalence of Metabolic Syndrome : Baseline Survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima, Japan
- Consumption of Seafood, Serum Liver Enzymes, and Blood Levels of PFOS and PFOA in the Japanese Population