Favorable Effects of Tea on Reducing the Cognitive Deficits and Brain Morphological Changes in Senescence-Accelerated Mice
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概要
- 論文の詳細を見る
The present study was carried out to explore the effects of oolong and green teas on improving the memory deficits and brain pathological changes in senescence accelerated-prone mice P8 (SAMP8). Six-month-old mice were supplied with oolong tea, green tea or water as the sole drinking fluid for 16wk. The memory ability of mice was evaluated by passive and active avoidance tests, while the extent of the brain degeneration was measured by the spongiosis grades and the lipofuscin percentage in the hippocampus. The total grading score and serum biochemical levels were also measured. The results indicated that the mice supplemented with the oolong and green tea drinks reversed the cognitive impairment, lessened the spongy degeneration and lipofuscin, and increased the serum Trolox equivalent antioxidant capacity more than the control group. The total grading score of the oolong tea group was lower than that of the control group in male mice, whereas it did not differ among female groups. No differentiations in the concentrations of total cholesterol, triglyceride, glucose, iron or hemoglobin were observed among three drink groups. In conclusion, oolong and green teas could reduce the deteriorations of cognitive ability, brain degenerative changes and aging process in SAMP8, probably through the potent antioxidative activity of the tea.
- 日本ビタミン学会の論文
著者
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YAMAMOTO Shigeru
Department of Nutrition and Food Science, Ochanomizu University
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Tsai Chin-ju
Department Of Food And Nutrition Providence University
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Yamamoto Shigeru
Dep. Of Nutrition And Food Sci. Ochanomizu Univ.
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WANG Ming-Fu
Department of Food and Nutrition, Providence University
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Wang M‐f
Department Of Food And Nutrition Providence University
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Wang Ming‐fu
Providence Univ. Taichung Twn
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Wang Ming-fu
Department Of Food And Nutrition Providence University
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YAMAMOTO Shigeru
International Nutrition, Ochanomizu University Graduate School of Humanities and Sciences
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Yamamoto Shigeru
Department Of International Nutrition Institute Of Health Biosciences The University Of Tokushima Gr
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CHAN Yin-Ching
Department of Food and Nutrition, Providence University
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HOSODA Kazuaki
Faculty of Wellness Studies, Kwassui Women's College
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Hosoda Kazuaki
Faculty Of Wellness Studies Kwassui Women's College
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Chan Yin-ching
Department Of Food And Nutrition Providence University
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Chan Yin-ching
Dep. Of Food And Nutrition Providence Univ.
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Yamamoto Shigeru
International Nutrition Ochanomizu University Graduate School Of Humanities And Sciences
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Yamamoto Shigeru
International Nutrition Department Of Food And Nutrition Jumonji University
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