Spirulina Prevents Memory Dysfunction, Reduces Oxidative Stress Damage and Augments Antioxidant Activity in Senescence-Accelerated Mice

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概要

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• Spirulina has proven to be effective in treating certain cancers, hyperlipidemia, immunodeficiency, and inflammatory processes. In this study, we aimed to investigate the effects of Spirulina on memory dysfunction, oxidative stress damage and antioxidant enzyme activity. Three-month-old male senescence-accelerated prone-8 (SAMP8) mice were randomly assigned to either a control group or to one of two experimental groups (one receiving daily dietary supplementation with 50 mg/kg BW and one with 200 mg/kg BW of Spirulina platensis water extract). Senescence-accelerated-resistant (SAMR1) mice were used as the external control. Results showed that the Spirulina-treated groups had better passive and avoidance scores than the control group. The amyloid β-protein (Aβ) deposition was significantly reduced at the hippocampus and whole brain in both Spirulina groups. The levels of lipid peroxidation were significantly reduced at the hippocampus, striatum, and cortex in both Spirulina groups, while catalase activity was significantly higher only in the 200 mg/kg BW Spirulina group than in the control group. Glutathione peroxidase activity was significantly higher only in the cortex of the 200 mg/kg group than in that of the SAMP8 control group. However, superoxide dismutase activity in all parts of the brain did not significantly differ among all groups. In conclusion, Spirulina platensis may prevent the loss of memory possibly by lessening Aβ protein accumulation, reducing oxidative damage and mainly augmenting the catalase activity.

• 財団法人 学会誌刊行センターの論文
• 2011-04-01

著者

• Wang Ming-fu

  Department Of Food And Nutrition Providence University

• Lee I-te

  Division Of Endocrinology And Metabolism Department Of Internal Medicine Taichung Veterans General H

• Chan Yin-ching

  Department Of Food And Nutrition Providence University

• HWANG Juen-Haur

  Department of Otolaryngology, Buddhist Dalin Tzu-Chi General Hospital

• JENG Kee-Ching

  Applied Mathematics, Providence University

• HOU Rolis

  Department of Biotechnology, Yuanpei University

• Hou Rolis

  Department Of Biotechnology Yuanpei University

• Wu Su-mei

  Department Of Food And Nutrition Providence University

• Hwang Juen-haur

  Department Of Otolaryngology Buddhist Dalin Tzu-chi General Hospital

• Jeng Kee-ching

  Applied Mathematics Providence University

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