Genistein Suppresses Development of Spontaneous Atopic-Like Dermatitis in NC/Nga Mice
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概要
- 論文の詳細を見る
In this study, we examined the effect of genistein on the severity of dermatitis and level of serum IgE in NC/Nga (NC) mice. NC mice housed in conventional conditions develop spontaneous atopic-like dermatitis; however, oral administration of 20mg/kg genistein suppresses the development of dermatitis. We also investigated the levels of serum IgE in genistein-treated NC mice and found that the levels were the same as those in control NC mice. We further investigated in vitro IFN-γ and IL-4 production from spleen cells upon stimulation with anti-CD3 and anti-CD28 mAbs. IFN-γ production level in NC mice that received 20mg/kg genistein was significantly lower than that in control NC mice. In contrast, the production level of IL-4 in genistein-treated mice was not significantly different from that in control mice but tended to increase in a dose-dependent manner.
- 日本ビタミン学会の論文
著者
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YAMAMOTO Shigeru
Department of Nutrition and Food Science, Ochanomizu University
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KOGISO Mari
Department of Chemistry and Bioscience, Faculty of Science, Kagoshima University
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Kogiso Mari
Department Of International Nutrition Institute Of Health Biosciences The University Of Tokushima Gr
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Kogiso Mari
Department Of Chemistry And Bioscience Faculty Of Science Kagoshima University
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Yamamoto Shigeru
Dep. Of Nutrition And Food Sci. Ochanomizu Univ.
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Yamamoto S
Department Of International Public Health Nutrition Institute Of Health Biosciences The University O
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SAKAI Tohru
Department of International Public Health Nutrition
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MITSUYA Kaori
Department of International Nutrition, Institution of Health Bioscience, The University of Tokushima
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KOMATSU Tatushi
Department of Clinical Nutrition, Osaka Prefecture University
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Sakai Tohru
Dep. Of Public Health And Applied Nutrition Inst. For Health Biosciences The Univ. Of Tokushima
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Sakai Tohru
Department Of Clinical Nutrition Osaka Prefecture University
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Sakai Tohru
Department Of International Nutrition Institute Of Health Biosciences The University Of Tokushima Gr
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Yamamoto Shigeru
Department Of International Nutrition Institute Of Health Biosciences The University Of Tokushima Gr
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Mitsuya Kaori
Department Of International Nutrition Institute Of Health Biosciences The University Of Tokushima Gr
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Komatsu Tatsushi
Department Of Clinical Nutrition Osaka Prefecture University
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Yamamoto Shigeru
International Nutrition Ochanomizu University Graduate School Of Humanities And Sciences
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Yamamoto Shigeru
Department Of Biology Faculty Of Science Kyushu University
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YAMAMOTO Shigeru
Department of International Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School
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SAKAI Tohru
Department of International Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School:Department of Clinical Nutrition, Osaka Prefecture University
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MITSUYA Kaori
Department of International Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School
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KOGISO Mari
Department of International Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School
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SAKAI TOHRU
Department of Chemical Engineering, Toyama University
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