Natural Killer(NK) cell activity of mice treated with herpes simplex virus type-2, sarcoma-180 cells, cyclosporine and cimetidine.
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概要
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NK cell activity in beige mice was compared with that in control BALB/c mice and BALB/c mice treated with HSV-2, sarcoma-180 cells, cimetidine and cyclosporine. The NK cell activity in five week-old beige mice was lower than in three week-old BALB/c mice. The NK cell activity in eight week-old BALB/c mice was four to eleven times the activity in BALB/c mice that were three weeks of age. BALB/e mice, injected with 2 mg cyclosporine or 10<SUP>7</SUP> plaque forming units (PFU) of HSV-2, had decreased NK cell activity. BALB/c mice, injected with 2 mg cimetidine, 10<SUP>6</SUP> sarcoma-180 cells and 6.0×10<SUP>5</SUP> PFU of HSV-2, had high NK cell activities compared with the control mice. Cimetidine further increased the effect of HSV-2 or sarcoma-180 on NK activity. BALB/c mice that received a transfer of less than 10<SUP>7</SUP> NK cells developed a high resistance against viral infections, but mice that received more than 10<SUP>7</SUP> transferred NK cells had a lower resistance to viral infections than the control mice or mice receiving less than 10<SUP>7</SUP> NK cells.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Kabuta Hidefumi
Department Of Biology Faculty Of Science Kyushu University
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Yamamoto Shigeru
Department Of Biology Faculty Of Science Kyushu University
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Tanaka Masatoshi
International Center For Theoretical Physics:japan Atomic Energy Research Institute
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SHINGU MASAHISA
Department of Microbiology, Kurume University School of Medicin
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NODA YASUTAKA
Experimental Animal Center, Kurume University School of Medicine
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NODA YASUTAKA
Experimental Animal Centers, Kurume University School of Medicine
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SHINGU MASAHISA
Department o f Microbiology, Kurume University School of Medicine
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TANAKA MASATOSHI
Internal Medicine, Kurume University School of Medicine
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