<SYMPOSIUM : Biology of Aging and Age-associated Skin Disorders>POSSIBLE ROLES OF ADVANCED GLYCATION END-PRODUCTS IN PROMOTING SKIN AGING
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概要
- 論文の詳細を見る
It has been reported that AGEs deposit in the dermal matrix of photoaging skin. However, the influence of AGEs on the aging process is still unclear. To investigate the effects of AGEs, we used the dermal fibroblast culture system. AGEs decreased the proliferation rate, the synthesis of both collagen and hyaluronic acid, and elastase activity. From the results, it is indicated that AGEs affects the proliferation and the matrix turnover of the dermis. Further, it was found that AGEs exposed to UVA generate active oxygen species, such as superoxide anions, hydrogen peroxides, and hydroxyl radicals, suggesting the possibility that AGEs deposited in the dermal tissue advance skin aging through both physiological and environmental conditions.
- 名古屋市立大学の論文
- 2000-01-31
著者
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SAKURAI Hiromu
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
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OKANO Yuri
Cosmos Technical Center Co. Ltd.
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正木 仁
日光ケミカルズ(株)
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Sakurai Hiromu
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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Sakurai H
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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Masaki Hitoshi
Nikkol Group Cosmos Technical Center Co. Ltd.
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Masaki H
Noevir Co. Ltd. Shiga Jpn
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OKANO Yuri
Kobe Research Laboratories, Noevir Co. Ltd.
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MASAKI Hitoshi
Kobe Research Laboratories, Noevir Co. Ltd.
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Masaki Hitoshi
コスモステクニカルセンター
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Mizutani Hiroshi
Research Laboratories Nippon Menard Cosmetic
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