Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes
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概要
- 論文の詳細を見る
We prepared 4 new Zn(II) complexes with Zn(O_4), Zn(N_2O_2), and Zn(S_2O_2) coordination modes and evaluated their insulinomimetic activities in an in vitro study. The insulinomimetic activities of bis(pyrrole-2-carboxylato)zinc (Zn(pc)_2), bis(α-furonic acidato)zinc (Zn(fa)_2), bis(thiophene-2-carboxylato)zinc (Zn(tc)_2), and bis(thiophene-2-acetato)zinc (Zn(ta)_2) complexes were found to be higher than that of zinc sulfate (ZnSO_4). Zn(ta)_2 showed the highest insulinomimetic activity among the Zn(II) complexes because of its high lipophilicity.
- 公益社団法人日本薬学会の論文
- 2008-08-01
著者
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SAKURAI Hiromu
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
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MATSUMOTO Kinuyo
Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University
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YOSHIKAWA Yutaka
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
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KAJIWARA Naemi
Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University
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Ueda Eriko
Department Of Chemistry Graduate School Of Science Osaka City University
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Sakurai Hiromu
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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Sakurai H
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Kajiwara Naemi
Laboratory Of Nutrition Physiology Graduate School Of Life Science Kobe Women's University
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Kajiwara Naemi
Laboratory Of Nutrition Physiology Faculty Of Home Economics Kobe Women's College
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Matsumoto Kinuyo
Laboratory Of Nutrition Physiology Graduate School Of Life Science Kobe Women's University
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NISHIDE Midori
Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University
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YOSHIKAWA Eriko
Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University
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Nishide Midori
Laboratory Of Nutrition Physiology Graduate School Of Life Science Kobe Women's University
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Yoshikawa Yutaka
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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Yoshikawa Eriko
Laboratory Of Nutrition Physiology Graduate School Of Life Science Kobe Women's University
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Ueda Eriko
Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University
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