A 4-WEEK SUBCUTANEOUS TOXICITY STUDY OF RECOMBINANT HUMAN INTERFERON αA (LBD-007) IN SPRAGUE-DAWLEY RATS
スポンサーリンク
概要
- 論文の詳細を見る
Recombinant human interferon αA (code name: LBD-007) was subcutaneously administered to both sexes of Sprague-Dawley rats at the doses of 0, 6, 12 and 24×10^6 IU/kg of body weight five days per week for 4 weeks to evaluate the subchronic toxicity. 20 to 50% of rats except the male control group showed minimal to mild, focal to multifocal renal mineralization. Whether renal mineralization is related to the test substance is not elucidated. Male rats dosed at 24×10^6 IU/kg showed the decrease of the absolute kidney weights and the increase of the brain relative weights. Female rats dosed at 24×10^6 IU/kg showed the increase of the absolute and relative ovary weights, and the decreases of specific gravity, bilirubin and urobilinogen in urine. However, no drug-related changes were noted in clinical findings, body weights, food consumption, water consumption, hematology, blood clinical chemistry and necropsy findings. Based on the results it is concluded that the estimated subcutaneous non-toxic dose of the recombinant human interferon αA (LBD-007) in rats is (6〜12)×10^6 IU/kg.
- 日本トキシコロジー学会の論文
著者
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Han Sang-seop
韓国
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Kim Hyoung-chin
Division Of Pathology National Institute Of Health Sciences
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Kang Boo-hyon
Korea Research Instiutute Of Bioscience And Biotechnology.
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Han S‐s
Pharmacokinetics & Toxicokinetics Lab. Toxicology Research Center Korea Research Institute Of Ch
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Han Sang-seop
Toxicology Research Center Korea Research Institute Of Chemical Technology
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Roh J‐k
Pharmacokinetics And Toxicokinetics Lab. Toxicology Research Center Korea Research Institute Of Chem
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ROH Jung-Koo
Toxicology Research Center Korea Research Institute of Chemical Technology
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Kim Hyoung-chin
Korea Research Instiutute Of Bioscience And Biotechnology.
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HA Chang-Su
Korea Research Institute of Chemical Technology
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Kim Hyoung-Chin
Toxicology Research Center, Korea Research Institute of Chemical Technology
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Kang Boo-Hyon
Toxicology Research Center, Korea Research Institute of Chemical Technology
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Ha Chang-Su
Toxicology Research Center, Korea Research Institute of Chemical Technology
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Han Sang-seop
Toxicol.res.ctr. Korea Research Institute Of Chemical Technology
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