AN ACUTE TOXICITY STUDY OF RECOMBINANT HUMAN INTERFERON αA (LBD-007) IN SPRAGUE-DAWLEY RATS
スポンサーリンク
概要
- 論文の詳細を見る
The acute toxicity of a recombinant human interferon αA (code name: LBD-007) was evaluated in both sexes of Sprague-Dawley rats, 5 weeks old, by the oral, subcutaneous and intravenous routes of administration. Based on the results, LBD-007was not considered to induce any toxicological effect on the rats in mortalities, clinical findings, body weights and gross findings. It is suggested that LD_<50> values in rats would be >48×10^8 IU/kg in the study of oral administration and >24×10^8 IU/kg in the study of subcutaneous or intravenous administration.
- 日本トキシコロジー学会の論文
著者
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Han Sang-seop
韓国
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Kim Hyoung-chin
Division Of Pathology National Institute Of Health Sciences
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Kang Boo-hyon
Korea Research Instiutute Of Bioscience And Biotechnology.
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Han S‐s
Pharmacokinetics & Toxicokinetics Lab. Toxicology Research Center Korea Research Institute Of Ch
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Han Sang-seop
Toxicology Research Center Korea Research Institute Of Chemical Technology
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Roh J‐k
Pharmacokinetics And Toxicokinetics Lab. Toxicology Research Center Korea Research Institute Of Chem
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ROH Jung-Koo
Toxicology Research Center Korea Research Institute of Chemical Technology
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Kim Hyoung-chin
Korea Research Instiutute Of Bioscience And Biotechnology.
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HA Chang-Su
Korea Research Institute of Chemical Technology
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Kim Hyoung-Chin
Toxicology Research Center, Korea Research Institute of Chemical Technology
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Kang Boo-Hyon
Toxicology Research Center, Korea Research Institute of Chemical Technology
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Ha Chang-Su
Toxicology Research Center, Korea Research Institute of Chemical Technology
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Han Sang-seop
Toxicol.res.ctr. Korea Research Institute Of Chemical Technology
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