<Abstract of Published Report>In Vitro and In Vivo Evaluation of Mini-depot Tablet Prepared Using Poly(DL-lactide-co-glycolide)nanoparticles as Retardant Material.
スポンサーリンク
概要
著者
-
Kawashima Y
Taisho Pharmaceutical Co. Ltd. Saitama Jpn
-
TAKEUCHI Hirofumi
Department of Pharmaceutical Engineering, Gifu Pharmaceutical University
-
Takeuchi H
Gifu Pharmaceutical Univ.
-
Kawashima Y
Department Of Pharmaceutical Engineering Gifu Pharmaceutical University
-
Kawashima Y
Gifu Pharmaceutical University
-
Kobayashi Masao
Product & Technology Development Laboratory Tanabe Seiyaku Co. Ltd.
関連論文
- Slow Release of Tetracycline from a Mucoadhesive Complex with Sucralfate for Eradication of Helicobacter pylori
- Development of Agglomerated Crystals of Ascorbic Acid for Direct Tableting by Spherical Crystallization Technique and Evaluation of Their Compactibilities.
- Formulation Design of Ointment Base Suitable for Healing of Lesions in Treatment of Bedsores.
- Mucoadhesive Liposomes : Physicochemical Properties and Release Behavior of Water-Solubule Drugs from Chitosan-Coated Liposomes.
- Modification of the Physicochemical Properties of Minocycline Hydrochloride Ointment with Cyclodextrines for Optimum Treatment of Bedsore.
- Formulation Design of Ointment Base Suitable for Healing of Lesions in Treatment of Bedsores
- Compaction Properties of Composite Particles Consisting of Lactose with Sodium Alginate Prepared by Spray-Drying.
- Formulation and in vivo evaluation of w/o/w emulsion encapsulating Epirubicin hydrochloride for the transcatheter arterial embolization therapy for hepatocellular carcinoma.
- Prolonged Circulation Time of Doxorubicin-loaded Liposomes Coated with a Modified Polyvinyl Alcohol after Intravenous Injection in Rats.
- Mixed Base of Hydrophilic Ointment and Purified Lanolin to Improve the Drug Release Rate and Absorption of Water of Minocycline Hydrochloride Ointment for Treatment of Bedsores.
- Comparison of Lipiodol Water-in-Oil-in-Water Emulsion and Oil-in-Water Emulsion : Acute Toxicity and Deposition in Liver after Hepatic Arterial Administration in Rats.
- Pulmonary Delivery of Insulin with Nebulized DL-Lactide/Glycolide Copolymer(PLGA) Nanospheres to Prolong Hypoglycemic Effect.
- Modification of the Physicochemical Properties of Minocycline Hydrochloride Ointment with Cyclodextrines for Optimum Treatment of Bedsore
- Surface-modified Antiasthmatic Dry Powder Aerosols Inhaled Intratracheally Reduce the Pharmacologically Effective Dose.
- A New Powder Design Method to Improve Inhalation Efficiency of Pranlukast Hydrate Dry Powder Aerosols by Surface Modification with Hydroxypropylmethylcellulose Phthalate Nanospheres.
- Preparation of Spherically Granulated Crystals of Waxy Drug(Tocopherol Nicotinate) for Direct Tableting by Spherical Crystallization Technique.
- Spray-dried Composite Particles of Lactose and Sodium Alginate for Direct Tabletting and Controlled Releasing.
- Design of Inhalation Dry Powder of Pranlukast Hydrate to Improve Dispersibility by the Surface Modification with Light Anhydrous Silicic Acid(AEROSIL 200)
- Effect of Surface Morphology of Carrier Lactose on Dry Powder Inhalation Property of Pranlukast Hydrate.
- Particle Design of Wogon Extract Dry Powder for Inhalation Aerosols with Granulation Method.
- Engineering of poly(DL-lactic-co-glycolic acid) nanocomposite particles for dry powder inhalation dosage forms of insulin with the spray-fluidized bed granulating system
- Tabletting of Solid Dispersion Particles Consisting of Indomethacin and Porous Silica Particles
- A new spherically agglomerated drug composite system with lactose for dry powder inhalation
- Design of rolipram-loaded nanoparticles : comparison of two preparation methods.
- Biodegradable Nanoparticles for Targeted Ddrug Delivery in Treatment of Inflammatory Bowel Disease.
- Mucoadhesive nanoparticulate systems for peptide drug delivery.
- Evaluation of the anti-tumour activity of liposomal doxorubicin coated with hydrophilic polymers in tumour-bearing mice.
- Surface Modification of Liposomes with Various Hydrophilic Polymers Bearing Hydrophobic Anchors and Their Circulation Properties.
- Preparation of a Gel-Forming Ointment Base Applicable to the Recovery Stage of Bedsore and Clinical Evaluation of a Treatment Method with Different Ointment Bases Suitable to each Stage of Bedsore.
- Evaluation of ciruclation profiles of liposomes coated with hydrophilic polymers having different molecular weights in rats.
- Passive Tartgeting of Doxorubicin with Polymer Coated Liposomes in Tumor Bearing Rats.
- Passive Targeting of Doxorubicin with Polymer Coated Liposomes in Tumor Bearing Rats
- In Vitro Inhalation Behavior of Spherically Agglomerated Steroid Particles with Carrier Lactose.
- Temperature-Induced Crystallization and Compactibility of Spray Dried Composite Particles Composed of Amorphous Lactose and Various Types of Water-Solbule Polymer.
- Mucoadhesive DL-Lactide/Glycolide Copolymer Nanospheres coated with Chitosan to Improve Oral Delivery of Elcatonin.
- Formulation of Gel-Formation Ointments with Hydrophilic Polymers for Treatment of Recovery Stage of Bedsore.
- Preparation of Powdered Phospholipid Nanospheres by Spray Drying in an Aqueous System with Sugars.
- Preparation of Powdered Phospholipid Nanospheres by Fluidized-Bed Granulating in an Aqueous System with Sugars.
- Polymer Coating of Liposomes with a Modified Polyvinyl Alcohol and Their Systemic Circulation and RES Uptake in Rats.
- Enhanced Tumour Accumulation of Doxorubicin with Polymer-coated Liposomes in Rats.
- 156 A CASE WITH ALSTROM SYNDROME DEVELOPING INSULlN-RESISTANT DIABETES
- The Effects of Surfactants on the Water Dispersibility of Spray Dried vitamin-E Powders.
- Evaluation of Acute Toxicity of Epirubicin Hydrochloride-encapsulating w/o/w Emulsion Administered to Rat for the Transcatheter Embolization Therapy for Hepatocellular Carcinoma.
- Formulation of w/o/w lipiodol emulsion encapsulating epirubicin hydrochloride for the transcatheter arterial embolization therapy for hepatocellular carcinoma.
- Control of Cimetidine Crystal Forms Using Colloidal Silica in Pharmaceutical Preparation Process.
- In Vitro and In Vivo Evaluation of Mini-depot Tablet Prepared Using Poly(DL-lactide-co-glycolide)nanoparticles as Retardant Material.
- Utilization of Poly(DL-lactide-co-glycolide)nanoparticles for Preparation of Mini-depot Tablets by Direct Compression.
- Further Application of a Modified Spontaneous Emulsification Solvent Diffusion Method to Various Types of PLGA and PLA Polymers for Preparation of Nanoparticles.
- Evaluation of Poly(DL-lactide-co-glycolide)Nanoparticles as Matrix Material for Direct Compression.
- Evaluation of poly(DL-lactide-co-glycolide) nanoparticles as matrix material for direct compression
- Preparation of poly(DL-lactide-co-glycolide)nanoparticles by modified spontaneous emulsification solvent diffusion method.
- Influence of the Degrees of Hydrolyzation and Polymerization of Poly(vinylalchol)on the Preparation and Properties of Poly(DL-lactide-co-glycolide)nanoparticle.
- Biodegradable submicron carriers for peptide drugs : Preparation of DL-lactide/glycolide copolymer(PLGA)nanospheres with nafarelin acetate by a novel emulsion-phase separation method in an oil system.
- Drug Releasing Properties and Tensile Strength of Dry-Coated Tablets Prepared with Spray-Dried Composite Particles of Lactose and Sodium Alginate.
- Spray-Dried Lactose Composite Particles Containing an Ion Complex of Alginate-Chitosan for Designing a Dry-Coated Tablet Having a Time-Controlled Releasing Function.
- Temperature- and Moisture-Induced Crystallization of Amorphous Lactose in Composite Particles with Sodium Alginate Prepared by Spray-Drying.
- In vitro inhalation behavior of spherically agglomerated steroid particles with carrier lactose
- Temperature-Induced Crystallization and Compactibility of Spray Dried Composite Particles Composed of Amorphous Lactose and Various Types of Water-Soluble Polymer
- The Development of an Aqueous Polymeric Enteric Coating System with Hydroxypropylmethylcellulose Phthalate Nanoparticles
- Physical Stability of Size Controlled Small Unilamellar Liposomes Coated with a Modified Polyvinyl Alcohol.
- Properties of a Peptide Containing DL-Lactide/glycolide Copolymer Nanospheres Prepared by Novel Emulsion Solvent Diffusion Methods.
- Optimum Heat Treatment Conditions for Masking the Bitterness of the Clarithromycin Wax Matrix
- Determination of Optimum Processing Temperature for Transformation of Glyceryt Monostearate
- Method of Evaluation of the Bitterness of Clarithromycin Dry Syrup
- Preparation of Controlled releasing Acrylic Polymer Microspheres of Acebutolol Hydrochloride and Those Powder Coated Microspheres with Sodium Alginate in a Polymeric Spherical Crystallization System.
- Improved Static Compression Behaviors and Tablettabilities of Spherically Agglomerated Crystals Produced by the Spherical Crystallization Technique with a Two-Solvent System.
- Parameters determining the agglomeration behaviour and the micromeritic properties of spherically agglomerated crystals prepared by the spherical crystallization technique with miscible solvent systems.
- Preparation of Controlled Releasing Acrylic Polymer Microspheres of Acebutolol Hydrochloride and Those Powder Coated Microspheres with Sodium Alginate in a Polymeric Spherical Crystallization System
- Improvements in flowability and compressibility of pharmaceutical crystals for direct tabletting by spherical crystallization with a two-solvent system.
- Improvement in Compressing Properties of Drug crystals Using a Spray-drying Technique.
- Aqueous colloidal polymer dispersions of biodegradable DL-lactide/glycolide copolymer as basis for latex films : a new approach for the development of biodegradable depot systems.
- Preparation of Powdered Redispersible Vitamin E Acetate Emulsion by Spray-Drying Technique.
- Preparation Method for Powder Dosage Form of Oily Drug (Vitamin E Nicotinate)
- Penetration of Outer Layered Particles of Agglomerate into Inner Intersticies of Agglomerate during Spherical Agglomeration in Liquid.
- Core-particle Design and Control of Coating Film by Suspension Coating with Chitosan.
- Penetration of Outer Layered Particles of Agglomerate into Inner Intersticies of Agglomerate during Spherical Agglomeration in Liquid
- Mixed Base of Hydrophilic Ointment and Purified Lanolin to Improve the Drug Release Rate and Absorption of Water of Minocycline Hydrochloride Ointment for Treatment of Bedsores
- Assessment of Inertial Separation Techniques Used for Pressurized Meterd Dose Inhalers to Evaluat Respiratory Deposition of Aerosolized Wogon Extract Dry Powder in vitro.
- Protective Effects of Chitosan and Liposomal Formulation for Enzymatic Degradation of Insulin and Their Absorption Promoting Effects in Intestinal Mucous Layer.
- Enteral Absorption of Insulin in Rats from Mucoadhesive Chitosan-Coated Liposomes.
- The Design of Inhalation Dry Powders by the Surface Modification of Drug Particles.
- Tabletting properties of bucillamine agglomerates prepared by the spherical crystallization technique.
- Stabilization of Lactide/Glycolide Copolymer(PLGA) Nanospheres with Peptide-drug by Freeze-drying.
- Aerosolization of Lactide/Glycolide Copolymer(PLGA)Nanospheres for Pulmonary Delivery of Peptide-drugs.
- The Analysis of Drug Release from Diluted Water/oil/water Emusions by a Model of the Rupture of Oil Membrane.
- Preparation of Agglomerated Crystals for Direct Tabletting and Microencapsulation by the Spherical Crystallization Technique with a Continuous System.
- In Vitro Drug Release Behavior of D, L-Lactide/Glycolide Copolymer (PLGA) Nanospheres with Nafarelin Acetate Prepared by a Novel Spontaneous Emulsification Solvent Diffusion Method.