Diastereoselective 1,6-Asymmetric Induction to Obtain Chiral 4-Hydroxyethylaminobutanones by Using Methyltitanium Triisopropoxide

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概要

• 論文の詳細を見る

• The reactions of (S)-4-amino-1-phenylbutanones (3a-e) with methyllithium, methylmagnesium bromide, and methyltitanium triisopropoxide were studied. The reaction of the (S)-4-hydroxyethylamino derivatives (3a and 3d) with methyltitanium triisopropoxide gave 4a and 4d by 1,6-asymmetric induction with diastereoselectivities of 78 and 70%.

• 社団法人日本薬学会の論文
• 1990-04-25

著者

• 高橋 浩

  Faculty Of Pharmaceutical Science Hoshi University

• 高橋 浩

  Institute of Medicinal Chemistry, Hoshi University

• 東山 公男

  Institute of Medicinal Chemistry, Hoshi University

• 服部 一夫

  Institute of Medical Chemistry, Hoshi University

• 上野 由美子

  Institute of Medical Chemistry, Hoshi University

• 東山 公男

  星薬科大学

• 上野 由美子

  Institute Of Medical Chemistry Hoshi University

• 服部 一夫

  Institute Of Medical Chemistry Hoshi University

• 東山 公男

  Faculty Of Pharmaceutical Science Hoshi University

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