Synthesis and Absolute Configuration of Optically Pure (S)- and (R)-Diarylmethylamines

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概要

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• Optically pure (1S, 1'S)-1-aryl-N-2'-hydroxy-1'-isopropylethyl-1-phenylmethylamines (2a-c) were synthesized by the asymmetric reaction of (E)-(S)-N-(2-hydroxy-1-isopropylethyl) arylmethylideneamines (1a-c) with phenyllithium. On the other hand, optically pure (1R, 1'S)-configuration compounds (4a-c) were synthesized from (E)-(S)-N-(2-hydroxy-1-isopropylethyl) phenylmethylideneamine (3) and aryllithiums. Other optically pure compounds, (1R, 1'R)- and (1S, 1'R)-amines (2b and 4b), were also synthesized. The absolute configurations of these chiral amines were determined by using circular dichroism spectroscopy and X-ray analysis.

• 社団法人日本薬学会の論文
• 1983-07-25

著者

• 高橋 浩

  Faculty Of Pharmaceutical Science Hoshi University

• 堀 俊彦

  Research And Development Division Rigaku Industrial Corporation

• 堀 俊彦

  Rigaku Denki Co., Ltd.

• 鈴木 雄二

  Kaken Pharmaceutical Co., Ltd.

• 鈴木 雄二

  Hoshi College Of Pharmacy

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