Asymmetric α-Substituted Phenethylamines. V. Synthesis of Chiral 1-Alkyl-2-phenylethylamines via Grignard Reaction of 4-Phenyl-1,3-oxazolidines

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概要

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• Chiral N-methyl-4-phenyl-1,3-oxazolidines (2a-e) having a methyl, ethyl, benzyl, isopropyl, and cyclohexyl group at the 2-position of the 1,3-oxazolidine ring were synthesized. Reactions of 2a-e with Grignard reagents gave (1R, 1'R)- and (1S, 1'R)-1-alkyl-and 1-cycloalkyl-N-2'-hydroxy-1'-phenylethyl-2-phenylethylamines (3a, 3b, 3d, 3e). The absolute configurations of (1R, 1'R)-3a and-3e were determined. (R)-1-Methyl-and (R)-1-cyclohexyl-2-phenylethylamines (4a, 4e) were obtained in high yield by hydrogenolysis of (1R, 1'R)-3a and -3e.

• 社団法人日本薬学会の論文
• 1985-11-25

著者

• 高橋 浩

  Faculty Of Pharmaceutical Science Hoshi University

• 高橋 浩

  Institute of Medicinal Chemistry, Hoshi University

• 東山 公男

  Institute of Medicinal Chemistry, Hoshi University

• 千田 康裕

  Institute of Medicinal Chemistry, Hoshi University

• 大西 啓

  Institute of Medicinal Chemistry, Hoshi University

• 大西 啓

  Institute Of Medicinal Chemistry Hoshi University

• 東山 公男

  星薬科大学

• 千田 康裕

  Institute Of Medicinal Chemistry Hoshi University

• 東山 公男

  Faculty Of Pharmaceutical Science Hoshi University

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