Asymmetric α-Substituted Phenethylamines. VI. : Synthesis and Analgesic Activity of Optically Pure (R)- and (S)-N-Akyl-1-cyclohexyl-2-phenylethylamines

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概要

• 論文の詳細を見る

• Optically pure (R)- and (S)-N-alkyl-1-cyclohexyl-2-phenylethylamine hydrochlorides (9a-r)were synthesized from (R)- and (S)-phenylglycine by means of a simple procedure. The analgesic activity of these compounds was evaluated by the acetic acid writhing method, and 9e, 9f, 9i-k, and 9m showed more potent activity than (-)-pentazocine hydrochloride. Moreover, the analgesic activities of 9a-e, 9h, 9i, 9m, and 9o-r were not antagonized by naloxone.

• 社団法人日本薬学会の論文
• 1986-05-25

著者

• 高橋 浩

  Faculty Of Pharmaceutical Science Hoshi University

• 高橋 浩

  Institute of Medicinal Chemistry, Hoshi University

• 千田 康裕

  Institute of Medicinal Chemistry, Hoshi University

• 吉井 利郎

  Institute of Medicinal Chemistry, Hoshi University

• 鈴木 勉

  Institute of Medicinal Chemistry, Hoshi University

• 柳浦 才三

  Institute of Medicinal Chemistry, Hoshi University

• 千田 康裕

  Institute Of Medicinal Chemistry Hoshi University

• 柳浦 才三

  星薬料大学・薬理学教室

• 柳浦 才三

  Department Of Pharmacology Hoshi College Of Pharmacy

• 吉井 利郎

  星薬料大学・薬理学教室

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