Highly Diastereoselective 1,5-Asymmetric Induction to 3-Oxazolidino-1-phenylpropan-1-ones by Using Organotitanium Triisopropoxides

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概要

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• The reaction of (S)-3-4'-isopropyl-1'-3'-oxazolidino-1-phenylpropan-1-ones (1a, 1b) with 4 mol eq of various organotitanium triisopropoxides in ether at room temperature for 18-20 h gave 1-alkyl(or aryl)-3-N-alkyl(or arymethyl)-N-1'-isopropyl-2'-hydroxyethylamino-1-phenyl-propan-1-ols (2a-h) in good yields.This 1,5-asymmetric induction proceeded with extremely high diastereoselectivity. The absolute configurations of 2d and 3d were determined by X-ray analysis.

• 社団法人日本薬学会の論文
• 1986-02-25

著者

• 高橋 浩

  Faculty Of Pharmaceutical Science Hoshi University

• 高橋 浩

  Institute of Medicinal Chemistry, Hoshi University

• 東山 公男

  Institute of Medicinal Chemistry, Hoshi University

• 棚橋 浩治

  Institute of Medicinal Chemistry, Hoshi University

• 大西 啓

  Institute of Medicinal Chemistry, Hoshi University

• 大西 啓

  Institute Of Medicinal Chemistry Hoshi University

• 東山 公男

  星薬科大学

• 棚橋 浩治

  Institute Of Medicinal Chemistry Hoshi University

• 東山 公男

  Faculty Of Pharmaceutical Science Hoshi University

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