Asymmetric Synthesis by Using the Chirality of l-Ephedrine. II. Synthesis of (R)-α-Phenylethylamine
スポンサーリンク
概要
- 論文の詳細を見る
The chiral hydrazone (II), obtained by the condensation of N-aminoephedrine with benzaldehyde, was reacted with Grignard reagent to give the chiral hydrazine (IVa) in almost 100% diastereomeric excess. On the other hand, the chiral hydrazone (III) was reduced by lithium aluminium hydride to give the chiral hydrazine (IV). Hydrogenolysis of the chiral hydrazine (IVa) gave (R)-α-phenylethylamine (Va) with more than 97% optical purity, and l-ephedrine used as a chiral auxiliary reagent was recovered.
- 公益社団法人日本薬学会の論文
- 1981-11-25
著者
-
高橋 浩
Hoshi Institute of Pharmaceutical Sciences
-
野口 博美
Hoshi Institute Of Pharmaceutical Sciences
-
富田 考一
Hoshi Institute Of Pharmaceutical Sciences
関連論文
- Asymmetric α-Substituted Phenethylamines. I. Synthesis of Optically Pure 1-Aryl-N-(2'-hydroxy-1'-isopropylethyl)-2-phenylethylamines
- l-エフェドリンのキラリティーを利用した合成 : アラニンおよびフェニルグリシンの不斉合成
- Asymmetric Synthesis by Using the Chirality of l-Ephedrine. III. Reaction of N-(Arylmethylideneamino) ephedrine with Benzylmagnesium Chloride and Phenyllithium
- (+)-erythro-2-Methylamino-1,2-diphenylethanolの絶対配位およびそのキラリティーを利用した不斉合成
- Unconjugated Chiral Azomethines : Structure of N-Isobutylidene Derivatives of (S)-α-Amino Acid Esters
- Spiro Heterocyclic Compounds. I. Synthesis of Spiro-[imidazolidine-4,3'-INDOLINE]-2,2', 5-triones
- Synthesis of Nitrophenylpiperidine N-Oxides and Their Reductive Intramolecular Ring-Closure
- Synthesis and Conformation of 4,5-Disubstituted 5,6-Dihydro-4H-imidazo[1,5,4-d, e]quinoxalines
- A New Synthesis of 5,6-Dihydro-4H-imidazo[1,5,4-d, e]quinoxaline-5-ones
- Synthesis of Condensed Quinoxalines. II. A New Synthesis of Pyrrolo- [2,3-b] quinoxalines
- Reaction of 6-Nitroquinoxalines with Potassium Cyanide
- Asymmetric Synthesis by Using the Chirality of l-Ephedrine. II. Synthesis of (R)-α-Phenylethylamine
- Reaction of Aromatic Heterocyclic Nitro Compounds with Potassium Cyanide. II
- Reaction of Aromatic Heterocyclic Nitro Compounds with Potassium Cyanide. III. Some Nitroquinoline 1-Oxides
- Reaction of Aromatic Heterocyclic Nitro Compound with Potassium Cyanide. I. 3-Nitroquinoline
- Studies on the Structures of Diazine N-Oxides. II. Dipole Moments of Some Alkoxy-derivatives of Pyrimidine, Pyridazine and their N-Oxides.