生薬「升麻」の薬理学的研究(第1報)北升麻の急性毒性と抗炎症作用

概要

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Pharmacological effect of isoferuric acid and crude extracts CD-2-to-6,obtained from the chinese crude drug "Shoma" (the rhizome of Cimicifuga dahurica MAXIM.), was examined in mice and rats. Isoferuric acid showed a significant hypothermic, anti-pyretic, analgesic, and anti-edematous effect. CD4 strongly reduced writhing responses and carrageenin edema. CD6 showed significant hypothermic and anti-pyretic effects. It also showed a marked reduction of writhing responses. However, CD6 did not show any inhibition of carrageenin edema or analgesic effect using the tail pressure test. Only a slight reduction of writhing responses and dextran edema was found in CD5. CD2 showed a tendency of preventing lactic acid-induced anal ulcer, and a slight inhibition of carrageenin edema. The significance of these pharmacological results was discussed.
公益社団法人日本薬学会の論文
1975-05-25