Chemicopharmacological Studies on Antispasmodic Action. VIII. On the Antagonistic Action of Atropine and its Methobromide to Acetylcholine with the Isolated Small Intestines of Mice.

スポンサーリンク

概要

• 論文の詳細を見る

• (1) The after-effect of Atr tends to increase the contractibility of samll intestines in mice to ACh. (2) The log concentration-action curves of ACh were obtained under a constant concentration of Atr. There was no depression of the maximum at each Atr. The reaction order n between ACh and its receptor was not changed significantly from 1. These results indicate the competitive nature of antagonism between ACh and Atr. (3) The estimate of n was not significantly different from 1.5 according to our results on the concentration-inhibition curve of Atr against a constant concentration of ACh. (4) By means of the log concentration-inhibtion curve of Atr-MeBr, the mode of action was shown to be competitive, the same as Atr, and the estimate of n was not significantly different from 1.5,either. The former has a little more effect than the latter.

• 社団法人日本薬学会の論文
• 1957-10-20

著者

• 木村 正康

  Pharmaceutical Institute Medical Faculty University Of Tokyo

• 高木 敬次郎

  Pharmaceutical Institute Medical Faculty University Of Tokyo

関連論文

• Chemicopharmacological Studies on Antispasmodic Action. VIII. On the Antagonistic Action of Atropine and its Methobromide to Acetylcholine with the Isolated Small Intestines of Mice.
• 鎮痙作用の薬品作用学的研究;アセチルコリンに対する競合的並びに非競合的拮抗について
• 鎮痙作用の薬品作用学的研究(第6報)ハツカネズミ小腸におけるアセチルコリンの用量作用曲線の推計学的処理について
• 鎮痙作用の薬品作用学的研究(第6報)ハツカネズミ小腸におけるアセチルコリンの用量作用曲線の推計学的処理について
• Chemicopharmacological Studies on Antispasmodic Action. IX. Precise Discrimination of Atropine-like Activity and Papaverine-like Activity as Competitive and Non-competitive Antagonism to Acetylcholine.
• Chemicopharmacological Studies on Antispasmodic Action. VII. Antagonism to Acetylcholine tested with Rectus Abdominis of Frog.

スポンサーリンク