New Antihypertensive Agents. III. Synthesis and Antihypertensive Activity of Some Arylalkyl Piperidines Carrying a Heterocycle at the 4-Position

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概要

• 論文の詳細を見る

• We synthesized a series of arylalkyl piperidines (II) carrying a heterocycle at the 4-position of piperidine and examined the hypotensive activities of the products. Compound 23 had the highest hypotensive activity in anesthetized normotensive rats (-78 mmHg, 30 mg/kg, i.p.) and compound 12 showed the strongest hypotensive activity (-95 mmHg, 30 mg/kg, p.o.) in unanesthetized spontaneously hypertensive rats. Only compound 16 produced a considerable decrease in blood pressure in both animal models.

• 社団法人日本薬学会の論文
• 1983-09-25

著者

• 粕谷 豊

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University

• 寺西 正行

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 粕谷 豊

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hoshi University

• 久保 和博

  Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 周藤 勝一

  Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,

• 重信 弘毅

  Faculty of Pharmaceutical Sciences, Univerisity of Tokyo

• 階上 万規子

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 重信 弘毅

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo

• 高井 春樹

  Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,

• 久保 和博

  Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.

• 小場瀬 宏之

  Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 周藤 勝一

  Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.

• 中溝 喜博

  Tokyo Research Laboratory Kyowa Hakko Kogyo Co. Ltd.

• 高井 春樹

  Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.

• 階上 万規子

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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