2,2'-Dithiodibenzamides as Inhibitors of Blood Platelet Aggregation
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概要
- 論文の詳細を見る
New and known analogues of 2,2'-dithiodibenzamide were synthesized and tested for various pharmacological actions. This series of compounds was found to inhibit collagen-and adenosine 5'-diphosphate-induced aggregations of blood platelets. 2,2'-Dithiobis (N-(2-hydroxypropyl) benzamide) (3,KF4939) was one of the most potent compounds in in vitro aggregometry studies. Compound 3 after oral administration also potently inhibited pulmonary thrombosis induced by arachidonic acid injection in mice and platelet aggregation ex vivo in rats. This compound may have clinical value as a new orally active inhibitor of platelet aggregation.
- 公益社団法人日本薬学会の論文
- 1985-03-25
著者
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久保 和博
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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周藤 勝一
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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久保 和博
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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橋本 惟
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.
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小野 健
Chemical Research And Development Division Permachem Asia Co. Ltd.
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山田 耕二
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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橋本 惟
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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新野 英樹
Chemical Research and Development Division, Permachem Asia Co., Ltd.
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中溝 章雄
Chemical Research and Development Division, Permachem Asia Co., Ltd.
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村山 涌
Chemical Research and Development Division, Permachem Asia Co., Ltd.
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中溝 章雄
Chemical Research And Development Division Permachem Asia Co. Ltd.
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新野 英樹
Chemical Research And Development Division Permachem Asia Co. Ltd.
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村山 涌
Chemical Research And Development Division Permachem Asia Co. Ltd.
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周藤 勝一
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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中溝 喜博
Tokyo Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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