Studies on Cardiotonic Agents. VI. Synthesis of Novel 4,5-Dihydro-3(2H)-pyridazinone Derivatives Carrying Some Benzoheterocycles at the 6-Position
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概要
- 論文の詳細を見る
Several benzothiazolyl, imidazobenzothiazolyl, benzothienyl, benzothienopyrimidinyl and quinazolinyl 4,5-dihydro-3(2H)-pyridazinones were synthesized and examined for cardiotonic activity in anesthetized dogs after i.v. administration. Among them, 4-methylamino-7-(2,3,4,5-tetrahydro-5-methyl-3-oxo-6-pyridazinyl)quinazoline (36) showed potent and long-lasting inotropic activity (relative potency=2.11,milrinone=1). The activity of 36 was more potent than indolidan (2) (relative potency=1.53) which is one of the most potent inotropic agents to date.
- 公益社団法人日本薬学会の論文
- 1991-02-25
著者
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久保 和博
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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大野 哲司
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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野本 裕二
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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高井 春樹
Pharmaceutical Research Laboratories, Fuji, Kyowa Hakko Kogyo Co., Ltd.,
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久保 和博
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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野本 裕二
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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高井 春樹
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
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