Effect of Benidipine Hydrochloride (KW-3049), on Cerebral Ischemia Induced by Bilateral Occlusion of the Common Carotid Arteries in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effect of benidipine on experimental cerebral ischemia was investigated in rats subjected to occlusion of the bilateral common carotid arteries. Benidipine (30 μg/kg, i.p.) improved neurological symptoms such as ataxia, convulsion and loss of righting reflex, and prolonged survival time after occlusion of the bilateral common carotid arteries. In the nicardipine (100 μg/kg, i.p.)-treated group, a similar effect was observed, whereas nifedipine (100,300 μg/kg, i.p.) and verapamil (300 μg/kg, i.p.) did not show any beneficial effect in this model. Furthermore, pretreatment with benidipine (30 μg/kg, i.p.) suppressed the increase in cerebral water content 3 h after the occlusion. Nicardipine (100 μg/kg, i.p.) showed a tendency to reduce the increase in cerebral water content, though the effect was not statistically significant. Nifedipine (100μg/kg, i.p.) produced no improvement. After occlusion of the bilateral common carotid arteries, depletion of adenosine triphosphate (ATP) and phosphocreatine (CP) and an accumulation of lactate occurred in a time-dependent manner. Prophylactic administration of benidipine (30 μg/kg, i.p.), 20 min before occlusion, attenuated the depletion of ATP and CP and the accumulation of lactate 3 h after the occlusion. Furthermore, post-treatment with benidipine 30 min after occlusion also suppressed these metabolic disorders. In conclusion, the beneficial effects of benidipine in this severe cerebral ischemia model show that the compound has advantages over nicardipine, nifedipine and verapamil. Thus, these results suggest that benidipine may be useful in the treatment of acute ischemic cerebral damage.
- 社団法人日本薬学会の論文
- 1993-05-15
著者
-
唐沢 啓
Department Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
-
久保 和博
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
-
白倉 史郎
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
-
久保 和博
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
-
久保 和博
Pharmaceutical Research Laboratories Fuji Kyowa Hakko Kogyo Co. Ltd.
-
白倉 史郎
Department Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
関連論文
- Diuretic Effects of KW-3902,a Novel Adenosine A_1-Receptor Antagonist, in Anesthetized Dogs
- Effects of KW-5092,a Novel Gastroprokinetic Agent, on Intestinal Water and Electrolyte Transport in Rats
- Cardiovascular Effects of Benidipine and Amlodipine in Isolated Tissues and Anesthetized Dogs
- The Novel Thromboxane A_2 Receptor Antagonist KW-3635 Abolishes the Cyclic Flow Reduction in the Canine Carotid Artery
- Anti-proliferative Effects of Benidipine Hydrochloride in Porcine Cultured Vascular Smooth Muscle Cells and in Rats Subjected to Balloon Catheter-Induced Endothelial Denudation
- Protective Effects of Benidipine against Myocardial Damage Following Ischemia and Reperfusion in the Isolated Perfused Rat Heart
- Diuretic Effects of KW-3902 (8-(Noradamantan-3-yl)-1,3-dipropylxanthine), a Novel Adenosine A_1 Receptor Antagonist, in Conscious Dogs
- 1,4 : 3,6-Dianhydrohexitol Nitrate Derivatives. II. Synthesis and Antianginal Activity of Aryl- or Arylcarbonylpiperazine Derivatives
- Effect of Benidipine Hydrochloride (KW-3049), on Cerebral Ischemia Induced by Bilateral Occlusion of the Common Carotid Arteries in Rats
- Synthesis of Piperidine Derivatives with a Quinazoline Ring System as Potential Antihypertensive Agents
- Spiropiperidines. I. Synthesis of 1'-Substituted Spiro [4H-3,1-benzoxazine-4,4'-piperidin]-2 (1H)-one Derivatives and Evaluation of Their Antihypertensive Activity
- Synthesis of 1-and 3-(1-Substituted 4-Piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines as Potential Antihypertensive Agents
- New Antihypertensive Agents. III. Synthesis and Antihypertensive Activity of Some Arylalkyl Piperidines Carrying a Heterocycle at the 4-Position
- 1,4 : 3,6-Dianhydrohexitol Nitrate Derivatives. I. Synthesis and Antianginal Activity of Alkylpiperazine Derivatives
- Studies on Cardiotonic Agents. V. Synthesis of 1-(6,7-Dimethoxy-4-quinazolinyl)piperidine Derivatives Carrying Various 5-Membered Heterocyclic Rings at the 4-Position
- Studies on Cadiotonic Agents. IV. : Sunthesis of Novel 1-(6,7-Dimethoxy-4-quinazolinyl)piperidine Derivatives Carrying Substituted Hydantoin and 2-Thiohydantoin Rings
- Studies on Cardiotonic Agents. III. : Synthesis of 1-[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]-3-substituted 2-Imidazolidinone and 2-Imidazolidinethione Derivatives
- Studies on Cardiotonic Agents. I. : Synthesis of Some Quinazoline Derivatives
- New Antihypertensive Agents. I. Synthesis and Antihypertensive Activity of Some 4-Piperidylbenzimidazolinone Derivatives
- Studies on Cardiotonic Agents. II. : Synthesis of Novel Phthalazine and 1,2,3-Benzotriazine Derivatives
- Synthesis and Pharmacological Evaluation of Piperidine Derivatives with Various Heterocyclic Rings at the 4-Position
- New Antihypertensive Agents. II. Studies on New Analogs of 4-Piperidylbenzimidazolinones
- 2,2'-Dithiodibenzamides as Inhibitors of Blood Platelet Aggregation
- Studies on Cardiotonic Agents. VII. Potent Cardiotonic Agent KF15232 with Myofibrillar Ca^ Sensitizing Effect
- Studies on Cardiotonic Agents. VI. Synthesis of Novel 4,5-Dihydro-3(2H)-pyridazinone Derivatives Carrying Some Benzoheterocycles at the 6-Position
- Flunarizineの脳血流量および脳酸素消費量に及ぼす作用について
- (E)-1-[Bis-(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride(flunarizine)の脳循環に対する作用について